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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제10호
- 발행연도
- 2021.10
- 수록면
- 1,401 - 1,408 (8page)
- DOI
- 10.4014/jmb.2108.08027
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초록· 키워드
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This study examined whether the oral administration of low-molecular-weight collagen peptide (LMCP) containing 3% Gly-Pro-Hyp with >15% tripeptide (Gly-X-Y) content could ameliorate osteoarthritis (OA) progression using a rabbit anterior cruciate ligament transection (ACLT) model of induced OA and chondrocytes isolated from a patient with OA. Oral LMCP administration (100 or 200 mg/kg/day) for 12 weeks ameliorated cartilage damage and reduced the loss of proteoglycan compared to the findings in the ACLT control group, resulting in dose-dependent (p < 0.05) improvements of the OARSI score in hematoxylin & eosin (H&E) and Safranin O staining. In microcomputed tomography analysis, LMCP also significantly (p < 0.05) suppressed the deterioration of the microstructure in tibial subchondral bone during OA progression. The elevation of IL-1β and IL-6 concentrations in synovial fluid following OA induction was dose-dependently (p < 0.05) reduced by LMCP treatment. Furthermore, immunohistochemistry illustrated that LMCP significantly (p < 0.05) upregulated type II collagen and downregulated matrix metalloproteinase-13 in cartilage tissue.
Consistent with the in vivo results, LMCP significantly (p < 0.05) increased the mRNA expression of COL2A1 and ACAN in chondrocytes isolated from a patient with OA regardless of the conditions for IL-1β induction. These findings suggest that LMCP has potential as a therapeutic treatment for OA that stimulates cartilage regeneration
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참고문헌 (35)
참고문헌 신청
Glyn-Jones S / 2015 / Osteoarthritis / Lancet 386:376~387
Le Graverand-Gastineau MP / 2010 / Disease modifying osteoarthritis drugs : facing development challenges and choosing molecular targets / Curr. Drug Targets 11:528~535
Gamble R / 2000 / Recommendations for the medical management of osteoarthritis of the hip and knee / Arthritis Rheum 43:1905~1915
Lee SA / 2018 / Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-κB signaling inhibition / Biomed. Pharmacother 103:1202~1211
Jeong DH / 2018 / Effects of oral glucosamine hydrochloride and mucopolysaccharide protein in a rabbit model of osteoarthritis / Int. J. Rheum. Dis 21:620~628
Le Graverand-Gastineau MP / 2010 / Disease modifying osteoarthritis drugs : facing development challenges and choosing molecular targets / Curr. Drug Targets 11:528~535
Gamble R / 2000 / Recommendations for the medical management of osteoarthritis of the hip and knee / Arthritis Rheum 43:1905~1915
Lee SA / 2018 / Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-κB signaling inhibition / Biomed. Pharmacother 103:1202~1211
Jeong DH / 2018 / Effects of oral glucosamine hydrochloride and mucopolysaccharide protein in a rabbit model of osteoarthritis / Int. J. Rheum. Dis 21:620~628
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