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논문 기본 정보

자료유형
학술저널
저자정보
Park Sung-Soo (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) Lim Seul Ki (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) Lee Jieun (SME Service Department Strategy and Planning Division Gwangju 61755 Republic of Korea) Park Hyo Kyeong (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) Kwon Min-Sung (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) Yun Misun (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) 김남희 (한국식품연구원부설 세계김치연구소) Oh Young Joon (Microbiology and Functionality Research Group World Institute of Kimchi Gwangju 61755 Republic of K) 최학종 (한국식품연구원부설 세계김치연구소)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제11호
발행연도
2021.11
수록면
1,568 - 1,575 (8page)
DOI
10.4014/jmb.2107.07024

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Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.

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