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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1,159 - 1,168 (10page)
- DOI
- 10.5187/jast.2021.e82
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초록· 키워드
오류제보하기
Ovotransferrin (OTF), an egg protein known as transferrin family protein, possess strong antimicrobial and antioxidant activity. This is because OTF has two iron binding sites, so it has a strong metal chelating ability. The present study aimed to evaluate the improved immune- enhancing activities of OTF hydrolysates produced using bromelain, pancreatin, and papain. The effects of OTF hydrolysates on the production and secretion of pro-inflammatory mediators in RAW 264.7 macrophages were confirmed. The production of nitric oxide (NO) was evaluated using Griess reagent and the expression of inducible nitric oxide synthase (iNOS) were evaluated using quantitative real-time polymerase chain reaction (PCR). And the production of pro-inflammatory cytokines (tumor necrosis factor [TNF]-α and interleukin [IL]-6) and the phagocytic activity of macrophages were evaluated using an ELISA assay and neutral red uptake assay, respectively. All OTF hydrolysates enhanced NO production by increasing iNOS mRNA expression. Treating RAW 264.7 macrophages with OTF hydrolysates increased the production of pro-inflammatory cytokines and the phagocytic activity. The production of NO and pro-inflammatory cytokines induced by OTF hydrolysates was inhibited by the addition of specific mitogen-activated protein kinase (MAPK) inhibitors. In conclusion, results indicated that all OTF hydrolysates activated RAW 264.7 macrophages by activating MAPK signaling pathway
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참고문헌 (34)
참고문헌 신청
Yuhuai Xie / 2019 / Polysaccharide from alfalfa activates RAW 264.7 macrophages through MAPK and NF-κB signaling pathways / International Journal of Biological Macromolecules 126:960~968
Young-min Ha / 2013 / Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways / International Journal of Biological Macromolecules 60:399~404
Waqas Ahmad / 2018 / Immunomodulatory effects of Tinospora crispa extract and its major compounds on the immune functions of RAW 264.7 macrophages / International Immunopharmacology 60:141~151
Fangfang Wu / 2018 / Immune-enhancing activities of chondroitin sulfate in murine macrophage RAW 264.7 cells / Carbohydrate Polymers 198:611~619
Fan Yang / 2019 / A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-κB signaling pathways / International Journal of Biological Macromolecules 140:895~906
Young-min Ha / 2013 / Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways / International Journal of Biological Macromolecules 60:399~404
Waqas Ahmad / 2018 / Immunomodulatory effects of Tinospora crispa extract and its major compounds on the immune functions of RAW 264.7 macrophages / International Immunopharmacology 60:141~151
Fangfang Wu / 2018 / Immune-enhancing activities of chondroitin sulfate in murine macrophage RAW 264.7 cells / Carbohydrate Polymers 198:611~619
Fan Yang / 2019 / A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-κB signaling pathways / International Journal of Biological Macromolecules 140:895~906
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