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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 175 - 183 (9page)
- DOI
- 10.5045/br.2021.2021045
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초록· 키워드
오류제보하기
Background With the emergence of tyrosine kinase inhibitors and the incorporation of stringent measurable residual disease (MRD) monitoring, risk stratification for BCR-ABL1-positive acute lymphoblastic leukemia (ALL) patients has changed significantly. However, whether this monitoring can replace conventional risk factors in determining whether patients need allogeneic stem cell transplantation is still unclear. This study aimed to determine the impact of BCR-ABL1 monitoring on the outcome of patients with BCR-ABL1-positive ALL after allogeneic stem cell transplantation.
Methods We retrospectively analyzed the survival outcome of patients with BCR-ABL1-positive ALL based on the quantification of BCR-ABL1 at 3 timepoints: the end of induction (timepoint 1), post-consolidation week 16 (timepoint 2), and the end of treatment for patients who were either transplant-eligible or non-transplant eligible (timepoint 3).
Results From 2006 to 2018, a total of 96 patients newly diagnosed with BCR-ABL1-positive ALL were treated with chemotherapy and tyrosine kinase inhibitors. Thirty-eight (41.3%) patients achieved complete remission, and 33 patients underwent allogeneic stem cell transplantation. Our data showed that pre-transplant MRD monitoring by real-time quantitative polymerase chain reaction had the highest correlation with survival in patients with BCR-ABL1-positive ALL, especially for those who underwent allogeneic stem cell transplantation.
Conclusion Patients without MRD pre-transplantation had superior survival compared with those who had MRD, and they had excellent long-term outcomes after allogeneic stem cell transplantation.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Loghavi S / 2015 / B-acute lymphoblastic leukemia/lymphoblastic lymphoma / Am J Clin Pathol 144:393~410
Swerdlow SH / 2016 / The 2016 revision of the World Health Organization classification of lymphoid neoplasms / Blood 127:2375~2390
Fielding AK / 2009 / Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era : results from the International ALL Trial MRC UKALLXII/ECOG2993 / Blood 113:4489~4496
Thomas DA / 2004 / Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate / Blood 103:4396~4407
Preti HA / 1994 / Philadelphia-chromosome-positive adult acute lymphocytic leukemia : characteristics, treatment results, and prognosis in 41patients / Am J Med 97:60~65
Swerdlow SH / 2016 / The 2016 revision of the World Health Organization classification of lymphoid neoplasms / Blood 127:2375~2390
Fielding AK / 2009 / Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era : results from the International ALL Trial MRC UKALLXII/ECOG2993 / Blood 113:4489~4496
Thomas DA / 2004 / Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate / Blood 103:4396~4407
Preti HA / 1994 / Philadelphia-chromosome-positive adult acute lymphocytic leukemia : characteristics, treatment results, and prognosis in 41patients / Am J Med 97:60~65
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