지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q34:q11). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.
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참고문헌 (41)
참고문헌 신청
Apperley JF / 2007 / Part II: management of resistance to imatinib in chronic myeloid leukaemia / Lancet Oncol 8:1116~1128
O'Brien SG / 2003 / Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia / N Engl J Med 348:994~1004
Rowley JD / 1973 / Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining / Nature 243:290~293
Druker BJ / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat Med 2:561~566
Traxler P / 2001 / Tyrosine kinase inhibitors: from rational design to clinical trials / Med Res Rev 21:499~512
O'Brien SG / 2003 / Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia / N Engl J Med 348:994~1004
Rowley JD / 1973 / Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining / Nature 243:290~293
Druker BJ / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat Med 2:561~566
Traxler P / 2001 / Tyrosine kinase inhibitors: from rational design to clinical trials / Med Res Rev 21:499~512
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