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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 192 - 198 (7page)
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초록· 키워드
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Background: Fibrates are widely used to treat hypertriglyceridemia, a risk factor for arteriosclerosis, but these com-pounds have been associated with renal dysfunction. This study aimed to investigate the effects of fibrates on renal function in relatively healthy adult subjects with no cardiovascular diseases.Methods: This retrospective study included 558 outpatients who were prescribed 160 mg fenofibrate (fenofibrate group) or 10 mg atorvastatin (control group) between August 2007 and October 2015. The groups were randomly matched using propensity scores at a 1:1 ratio. Serum creatinine levels and estimated glomerular filtration rates be-fore and after treatment were compared between the two groups.Results: Patients in the fenofibrate group showed greater changes in serum creatinine levels than those in the con-trol group (9.73%±9.83% versus -0.89%±7.37%, P<0.001). Furthermore, 55.1% of patients in the fenofibrate group, but only 6.1% of those in the control group, exhibited a serum creatinine level increase ≥0.1 mg/dL (P<0.001). The fenofibrate group showed significantly greater declines in the estimated glomerular filtration rate than the control group (-10.1%±9.48% versus 1.42%±9.42%, P<0.001). Moreover, 34.7% of the fenofibrate group, but only 4.1% of the control group, exhibited an estimated glomerular filtration rate decrease ≥10 mL/min·1.73 m2 (P<0.001).Conclusion: Fenofibrate treatment resulted in increased serum creatinine levels and reduced estimated glomeru-lar filtration rates in a primary care setting. Therefore, regular renal function monitoring should be considered es-sential during fibrate administration.
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참고문헌 (35)
참고문헌 신청
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Baigent C / 2005 / Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins / Lancet 366:1267~1278
Cho JH / 2013 / Effect of fenofibrate therapy on blood creatinine levels in patients with hypertension and hypertriglyceridemia / J Lipid Atheroscler 2:19~26
Stone NJ / 2014 / ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / J Am Coll Cardiol 63(25Pt B):2889~2934
National Cholesterol Education Program Expert Panel on Detection / 2002 / Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report / Circulation 106:3143~3421
Baigent C / 2005 / Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins / Lancet 366:1267~1278
Cho JH / 2013 / Effect of fenofibrate therapy on blood creatinine levels in patients with hypertension and hypertriglyceridemia / J Lipid Atheroscler 2:19~26
Stone NJ / 2014 / ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / J Am Coll Cardiol 63(25Pt B):2889~2934
National Cholesterol Education Program Expert Panel on Detection / 2002 / Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report / Circulation 106:3143~3421
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