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논문 기본 정보

자료유형
학술저널
저자정보
Chung Lindsey Yoojin (Department of Pediatrics Myongji Hospital Hanyang University College of Medicine Goyang Korea.Depar) Kang Eungu (Department of Pediatrics Korea University College of Medicine Seoul Korea.) Nam Hyo-Kyoung (Department of Pediatrics Korea University College of Medicine Seoul Korea.) Rhie Young-Jun (Department of Pediatrics Korea University College of Medicine Seoul Korea.) Lee Kee-Hyoung (Department of Pediatrics Korea University College of Medicine Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.34
발행연도
2021.8
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2021.36.e219

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Background: Triptorelin depot is largely used to treat central precocious puberty (CPP) in children, and a 3-month depot has been introduced. However, data about the 3-month gonadotropin-releasing hormone use for treatment of CPP in Korean girls are not available. This study was conducted to compare the efficacy of a triptorelin 11.25 mg 3-month depot with that of a 3.75 mg 1-month depot in suppressing pubertal development for the treatment of CPP. Methods: A retrospective study, including 106 girls with CPP treated with triptorelin, was conducted. Fifty patients were treated with a triptorelin 3-month depot, and 56 were treated with a triptorelin 1-month depot. Serum luteinizing hormone (LH), follicle-stimulating hormone, and estradiol levels were analysed every 6 months after the visit. The height and bone age of each patient was evaluated at the beginning of treatment, after 6 months, and one year after therapy. Results: The baseline characteristics of the girls treated with a 3-month depot were similar to those of the girls treated with a 1-month depot. A suppressed levels of LH to the triptorelin injection (serum LH < 2.5 IU/L) at 6 months was seen in 90.0% and 98.2% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.160). After 1 year of treatment, a suppressed levels of LH was seen in 93.5% and 100% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.226). Height velocity showed no significant difference between the two groups. Degree of bone age advancement decreased from 1.22 ± 0.07 and 1.22 ± 0.08 years at baseline (P = 0.914) to 1.16 ± 0.07 and 1.17 ± 0.08 in the girls treated with the 3-month and 1-month depots after 1 year, respectively (P = 0.481). Conclusion: This study showed that the efficacy of long-acting triptorelin 3-month was comparable to 1-month depot regarding hormonal suppression and inhibition of bone maturation. The triptorelin 11.25 mg 3-month depot is an effective treatment for girls with CPP.
#Central Precocious Puberty #Triptorelin Pamoate #Gonadotropin-releasing Hormone Analogue #Korea

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참고문헌 (28)

참고문헌 신청
Nebesio TD / 2007 / Current concepts in normal and abnormal puberty / Curr Probl Pediatr Adolesc Health Care 37(2):50~72 google schola Nathan BM / 2005 / Regulation and disorders of pubertal timing / Endocrinol Metab Clin North Am 34(3):617~641 google schola Carel JC / 2009 / Consensus statement on the use of gonadotropin-releasing hormone analogs in children / Pediatrics 123(4):e752~e762 google schola 김유진 / 2013 / Multicenter clinical trial of leuprolide acetate depot (Luphere depot 3.75 mg) for efficacy and safety in girls with central precocious puberty / Annals of Pediatric Endocrinology & Metabolism 18(4):173~178 dbpia Müller J / 2000 / Hormonal changes during GnRH analogue therapy in children with central precocious puberty / J Pediatr Endocrinol Metab 13(Suppl 1):739~746 google schola

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