지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 895 - 902 (8page)
- DOI
- 10.3349/ymj.2021.62.10.895
이용수
초록· 키워드
오류제보하기
Purpose: Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Previous studies have shown that alisol A has anticancer potential. In this study, we explored the effect of alisol A on the growth of nasopharyngeal carcinoma (NPC) cells.
Materials and Methods: MTT assay, colony formation assay, flow cytometry, transwell assay, wound healing assay, and western blotting were used to assess cell viability, proliferation, cell cycle, migration, invasion, and protein expression, respectively, in vitro. AutoDock Vina and Discovery Studio software were used for molecular docking.
Results: Alisol A inhibited the viability, proliferation, migration, and invasion of NPC cells. The molecular docking simulation assay confirmed that alisol A bound to YAP protein. In addition, alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells.
Conclusion: Alisol A inhibited the proliferation, migration, and invasion of NPC cells by inhibiting the Hippo signaling pathway. Alisol A may be a candidate drug for NPC.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Fan C / 2018 / The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma / J Cancer 9:2852~2864
Lin DC / 2014 / The genomic landscape of nasopharyngeal carcinoma / Nat Genet 46:866~871
Chang ET / 2017 / Active and passive smoking and risk of nasopharyngeal carcinoma : a population-based case-control study in Southern China / Am J Epidemiol 185:1272~1280
Nakanishi Y / 2017 / Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma / Cancer Metastasis Rev 36:435~447
Fan C / 2018 / The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma / J Cancer 9:2852~2864
Lin DC / 2014 / The genomic landscape of nasopharyngeal carcinoma / Nat Genet 46:866~871
Chang ET / 2017 / Active and passive smoking and risk of nasopharyngeal carcinoma : a population-based case-control study in Southern China / Am J Epidemiol 185:1272~1280
Nakanishi Y / 2017 / Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma / Cancer Metastasis Rev 36:435~447
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Tolfenamic Acid Inhibits the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma: Involvement of p38-Mediated Down-Regulation of Slug
Yonsei Medical Journal
2016 .01
-
Effects of TESTIN Gene Expression on Proliferation and Migration of the 5-8F Nasopharyngeal Carcinoma Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
상근피의 Hippo 신호전달 경로 활성화를 통한 YAP 억제 효능
동의생리병리학회지
2019 .08
-
상근피의 Hippo 신호전달 경로 활성화를 통한 YAP 억제 효능
동의생리병리학회지
2019 .01
-
The regulatory effect of Alisma Rhizomes and their triterpenoids on α3β4 nicotinic acetylcholine receptor activity
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Hepatic Hippo signaling inhibits development of hepatocellular carcinoma
Clinical and Molecular Hepatology
2020 .01
-
유방암세포에서 LATS1/2 활성에 의한 당귀 추출물의 항암효과
동의생리병리학회지
2020 .08
-
Hippo Signal Transduction Mechanisms in T Cell Immunity
Immune Network
2020 .10
-
YAP phosphorylation is strongly suppressed during development of human endometrial cancer
한국실험동물학회 학술발표대회 논문집
2020 .02
-
택사의 Alisol B, Alisol B acetate 함량과 안정성
생약학회지(Korean Journal of Pharmacognosy)
2017 .12
-
ZNF488 Enhances the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma Via the Wnt Signaling Pathway Involving Epithelial Mesenchymal Transition
Cancer Research and Treatment
2016 .01
-
Immunohistochemical Expression of Cytokeratins and Epithelial Membrane Protein 2 in Nasopharyngeal Carcinoma and its Potential Implications
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy
Allergy, Asthma & Immunology Research
2017 .01
-
비인두암의 한의학적 진료 지침 개발을 위한 기초 연구
대한한방내과학회지
2016 .01
-
Plasma Macrophage Migration Inhibitory Factor and CCL3 as Potential Biomarkers for Distinguishing Patients with Nasopharyngeal Carcinoma from High-Risk Individuals Who Have Positive Epstein-Barr Virus Capsid Antigen-Specific IgA
Cancer Research and Treatment
2019 .01
-
Anti-Cancer Effects of the Pandanus tectorius Parkinson Extract: Reduction of YAP and TAZ Levels via Inhibition of the Hippo and Notch Signaling Pathways
대한의생명과학회지
2024 .09
-
DNA Methylation Biomarkers for Nasopharyngeal Carcinoma: Diagnostic and Prognostic Tools
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Yes-Associated Protein Expression Is Correlated to the Differentiation of Prostate Adenocarcinoma
Journal of Pathology and Translational Medicine
2017 .07
-
Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor
Radiation oncology journal : ROJ
2015 .01
-
Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell
Yonsei Medical Journal
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0