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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 117 - 124 (8page)
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The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial cells, which play an important role in inflammatory glomerular injury. We also found that co-treatment with cytokines at low doses (TNF-α; 5 ng/ml, IFN-γ; 5 ng/ml, and IL-1β; 1.25 U/ml) synergistically induced NO production, whereas treatment with each cytokine alone did not increase NO production at doses up to 100 ng/ml or 50 U/ml. Silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), attenuates cytokine mixture (TNF-α, IFN-γ, and IL-1β)-induced NO production. Western blot and RT-PCR analyses showed that silymarin inhibits inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner.
Silymarin also inhibited extracellular signal-regulated protein kinase-1 and -2 (ERK1/2) phosphorylation. Collectively, we have demonstrated that silymarin inhibits NO production in mouse mesangial cells, and may act as a useful anti-inflammatory agent.
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참고문헌 (44)
참고문헌 신청
Vianna HR / 2011 / Inflammation in chronic kidney disease : the role of cytokines / J Bras Nefrol 33:351~364
Betjes MG / 2013 / Immune cell dysfunction and inflammation in endstage renal disease / Nat Rev Nephrol 9:255~265
Radeke HH / 1992 / The inf lammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system / Clin Investig 70:825~842
Klahr S / 1997 / Oxygen radicals and renal diseases / Miner Electrolyte Metab 23:140~143
Marx M / 1993 / Renal matrix and adhesion in injury and inflammation / Curr Opin Nephrol Hypertens 2:527~535
Betjes MG / 2013 / Immune cell dysfunction and inflammation in endstage renal disease / Nat Rev Nephrol 9:255~265
Radeke HH / 1992 / The inf lammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system / Clin Investig 70:825~842
Klahr S / 1997 / Oxygen radicals and renal diseases / Miner Electrolyte Metab 23:140~143
Marx M / 1993 / Renal matrix and adhesion in injury and inflammation / Curr Opin Nephrol Hypertens 2:527~535
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