지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 465 - 474 (10page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to determine the raising anticancer effects of resveratrol (Res) on paclitaxel (PA) in non-small cell lung cancer (NSCLC) cell line A549. The 10 μg/ml of Res had no effect on human fetal lung fibroblast MRC-5 cells or on A549 cancer cells and the 5 or 10 μg/ml of PA also had no effect on MRC-5 normal cells. PA-L (5 μg/ml) and PA-H (10 μg/ml) had the growth inhibitory effects in NSCLC cell line A549, and Res increased these growth inhibitory effects. By flow cytometry experiment, after Res (5 μg/ml)+PA-H (10 μg/ml) treatment, the A549 cells showed the most apoptosic cells compared to other group treatments, and after additional treatment with Res, the apoptosic cells of both two PA concentrations were raised.
Res+PA could reduce the mRNA and protein expressions of COX-2, and Res+PA could reduce the COX-2 related genes of VEGF, MMP-1, MMP-2, MMP-9, NF-κB, Bcl-2, BclxL, procollagen I, collagen I, collagen III and CTGF, TNF-α, IL-1β, iNOS and raise the TIMP-1, TIMP-2, TIMP-3, IκB-α, p53, p21, caspase-3, caspase-8, caspase-9, Bax genes compared to the control cells and the PA treated cells. From these results, it can be suggested that Res could raise the anticancer effects of PA in A549 cells, thus Res might be used as a good sensitizing agent for PA.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Davidson M / 2016 / Clinical role of ramucirumab alone or in combination with paclitaxel for gastric and gastro-esophageal junction adenocarcinoma / Onco Targets Ther 9:4539~4548
Yu B / 2016 / Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes / Mater Sci Eng C Mater Biol Appl 68:579~584
Cunha KS / 2001 / Taxanes : the genetic toxicity of paclitaxel and docetaxel in somatic cells of Drosophila melanogaster / Mutagenesis 16:79~84
Shi WQ / 2011 / Historical story on natural medicinal chemistry of Taxol / Chinese Tradi Herbal Drug 42:1878~1884
Liu D / 2013 / Paclitaxel induced apoptotic genes and pathways alterations : a review / Sheng Wu Gong Cheng Xue Bao 29:153~160
Yu B / 2016 / Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes / Mater Sci Eng C Mater Biol Appl 68:579~584
Cunha KS / 2001 / Taxanes : the genetic toxicity of paclitaxel and docetaxel in somatic cells of Drosophila melanogaster / Mutagenesis 16:79~84
Shi WQ / 2011 / Historical story on natural medicinal chemistry of Taxol / Chinese Tradi Herbal Drug 42:1878~1884
Liu D / 2013 / Paclitaxel induced apoptotic genes and pathways alterations : a review / Sheng Wu Gong Cheng Xue Bao 29:153~160
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Self-efficacy to Engage in Physical Activity and Overcome Barriers, Sedentary Behavior, and Their Relation to Body Mass Index Among Elderly Indonesians With Diabetes
예방의학회지
2019 .01
-
Laparoscopic and Robotic Surgeries for Patients With Colorectal Cancer Who Have Had a Previous Abdominal Surgery
Annals of Coloproctology
2017 .01
-
Erratum to “Distribution of Seven N-Nitrosamines in Food” : [Toxicol. Res. 31 (2015) 279-298]
Toxicological Research
2018 .10
-
Erratum to “Anti-Diabetic Effect of Dung Beetle Glycosaminoglycan on db Mice and Gene Expression Profiling” : [Toxicol. Res. 34(2018) 151-162]
Toxicological Research
2018 .10
-
Objectively Measured Physical Activity of Vietnamese Adults With Type 2 Diabetes: Opportunities to Intervene
예방의학회지
2019 .01
-
국민건강증진종합계획의 신체활동분야 계획 변천과 발전방향: 1~4차 계획을 중심으로
보건교육건강증진학회지
2020 .03
-
An integrative review of physical activity in adults with inflammatory bowel disease
Intestinal research
2022 .01
-
풍지(風池)(GB20) 억간산(抑肝散) 약침이 국소 뇌손상으로 유발된 흰쥐의 인지장애에 미치는 영향
대한침구의학회지
2016 .01
-
Corrigendum to "Systematic Review of Acupuncture Treatment for Mild Cognitive"[J Acupunct Res 2019;36(2):72-79]
대한침구의학회지
2019 .01
-
건강증진을 위한 신체활동 정책 내용 고찰 : 신체활동 실천율을 기반으로
보건교육건강증진학회지
2016 .09
-
Meeting Recommended Levels of Physical Activity in Relation to Preventive Health Behavior and Health Status Among Adults
예방의학회지
2017 .01
-
Physical Activity of Patients with Chronic Schizophrenia and Related Clinical Factors
PSYCHIATRY INVESTIGATION
2018 .01
-
A Pseudoaneurysm Associated with a Ruptured Cerebral Aneurysm: Hypothesis on the Formation of the PA and Feasibility of Endovascular Treatment
Journal of Cerebrovascular and Endovascular Neurosurgery
2018 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
비소세포폐암 줄기세포에서 로즈마린산의 항증식 효과
생약학회지(Korean Journal of Pharmacognosy)
2024 .09
-
The Relationship between Physical Activity Intensity and Mental Health Status in Patients with Breast Cancer
Journal of Korean Medical Science
2017 .01
-
Role of repeat procalcitonin estimation at 48 hours for outcome in pregnancy associated sepsis: a prospective observational study
Obstetrics & Gynecology Science
2021 .01
-
Paclitaxel inhibits the hyper-activation of spleen cells by lipopolysaccharide and induces cell death
Journal of Veterinary Science
2016 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0