지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 115 - 120 (6page)
이용수
초록· 키워드
오류제보하기
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect of duloxetine (DXT), a potent and balanced serotonin/norepinephrine reuptake inhibitor, on CCH-induced neuronal damage in the hippocampal CA1 region using a rat model of permanent bilateral common carotid arteries occlusion. We found that treatment with 20 mg/kg DXT could attenuate the neuronal damage, the reduction of phosphorylations of mTOR and p70S6K as well as the elevations of $TNF-{\alpha}$ and $IL-1{\beta}$ levels in the hippocampal CA1 region at 28 days following CCH. These results indicate that DXT displays the neuroprotective effect against CCH-induced hippocampal neuronal death, and that neuroprotective effect of DXT may be closely related with the attenuations of CCH-induced decrease of mTOR/p70S6K signaling pathway as well as CCH-induced neuroinflammatory process.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Cechetti, F. / 2012 / Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment / Brain Res. Bull. 87:109~116
Choi, H. S. / 2015 / The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice / J. Neurol. Sci. 358:390~397
Dufner, A. / 1999 / Ribosomal S6 kinase signaling and the control of translation / Exp. Cell Res. 253:100~109
Farkas, E. / 2004 / Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain / Acta Neuropathol. 108:57~64
Farkas, E. / 2007 / Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases / Brain Res. Rev. 54:162~180
Choi, H. S. / 2015 / The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice / J. Neurol. Sci. 358:390~397
Dufner, A. / 1999 / Ribosomal S6 kinase signaling and the control of translation / Exp. Cell Res. 253:100~109
Farkas, E. / 2004 / Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain / Acta Neuropathol. 108:57~64
Farkas, E. / 2007 / Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases / Brain Res. Rev. 54:162~180
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
Journal of Veterinary Science
2017 .03
-
Effects of melatonin on cognitive impairment and hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Evaluation of chronic cerebral hypoperfusion model in mouse
한국실험동물학회 학술발표대회 논문집
2018 .07
-
원지(遠志)가 뇌혈류 저하에 의한 흰쥐 뇌조직의 산화적 손상과 해마신경세포 자연사에 미치는 영향
대한본초학회지(본초분과학회지)
2016 .01
-
Intralesional collagenase Clostridium histolyticum vs. verapamil injections in males with Peyronie’s Disease: A prospective, matched-pair, non-blinded, randomised clinical study comparing clinical outcomes and patient satisfaction rates
Investigative and Clinical Urology
2022 .09
-
Neuroprotective Agents in the Intensive Care Unit: Neuroprotective Agents in ICU
Journal of Pharmacopuncture
2018 .01
-
Neurocognitive Dysfunction According to Hypoperfusion Territory in Patients With Moyamoya Disease
Annals of Rehabilitation Medicine
2017 .01
-
Quercetin protects neuronal cells against focal cerebral ischemia and glutamate-induced damage via inhibition of apoptotic pathway
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Atopy-induced stress increases hippocampal neuroinflammatory damage in an atopic dermatitis mouse model
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Cyanidin-3-glucoside inhibits amyloid β25-35-induced neuronal cell death in cultured rat hippocampal neurons
The Korean Journal of Physiology & Pharmacology
2018 .11
-
Differential Expression of Vascular Endothelial Growth Factor in the Cortex and Hippocampus upon Cerebral Hypoperfusion
대한체질인류학회 학술대회 연제 초록
2020 .08
-
Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Gadd45b Acts as Neuroprotective Effector in Global Ischemia- Induced Neuronal Death
International Neurourology Journal
2019 .01
-
Neuroprotective Effects of ROS/RNA scavengers on Neurotoxicity in Organotypic Hippocampal Slice Cultures
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Effectiveness range and persistence of transcranial direct current stimulation against neuronal death by the transient cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Neuroprotective effects of mulberry fruit on H2O2-induced oxidative neuronal damage via MAPK/NF-κB signaling pathway in SH-SY5Y neuroblastoma cells
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Neuroprotective effects of herbal mixture HT070 on global cerebral ischemia in rats
대한본초학회지(본초분과학회지)
2016 .01
-
Cilostazol attenuates kainic acid-induced hippocampal cell death
The Korean Journal of Physiology & Pharmacology
2018 .01
-
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion
The Korean Journal of Physiology & Pharmacology
2017 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0