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논문 기본 정보

자료유형
학술저널
저자정보
Saeed Baradwan (Faisal Specialist Hospital and Research Center) Sahar Hassan Abdulghani (King Khalid University Hospital) Mohammed Abuzaid (King Fahad Medical City) Khalid Khadawardi (Umm Al-Qura University) Majed Saeed Alshahrani (Najran University) Abdulrahman Al-Matary (King Fahad Medical City) May A. AlRasheed (King Saud Hospital) Najlaa Talat Miski (King Abdulaziz University) Aroob Abdulhalim (Umm Al-Qura University) Yousra Mansour Alturki (Umm Al-Qura University) Ahmed Abu-Zaid (University of Tennessee Health Science Center)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제64권 제6호
발행연도
2021.11
수록면
484 - 495 (12page)

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To perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) that investigated theclinical benefits of 17-alpha hydroxyprogesterone caproate (17OHPC) in the prevention of recurrent preterm birth (PTB)among singleton pregnant women with a previous history of PTB. We searched four major databases up till April 2021and assessed the risk of bias in the included studies. We meta-analyzed various maternal-neonatal endpoints (n=18)and pooled them as mean difference or risk ratio (RR) with 95% confidence interval (CI) using the random-effectsmodel. Six RCTs met the inclusion criteria, comprising 2,573 patients (17OHPC=1,617, control=956). RCTs revealed anoverall low risk of bias. The rates of PTB <35 weeks (n=5 RCTs; RR, 0.77; 95% CI, 0.63-0.93; P=0.008), PTB <32 weeks(n=3 RCTs; RR, 0.68; 95% CI, 0.51-0.91; P=0.009), neonates with low birth weight (<2.5 kg) at delivery (n=3 RCTs; RR,0.63; 95% CI, 0.5-0.79; P<0.001), and neonatal death (n=4 RCTs; RR, 0.41; 95% CI, 0.20-0.84; P=0.02) were significantlyreduced in the 17OHPC group compared with the control group. Moreover, 17OHPC treatment correlated with asignificantly decreased rate of retinopathy (n=2 RCTs; RR, 0.42; 95% CI, 0.18-0.97; P=0.004). However, there were nosignificant differences in the rates of neonatal intensive care unit admission, cesarean delivery, and other pretermrelatedcomplications between both the groups. Among singleton pregnant women with a prior history of PTB,17OHPC may favorably decrease the risks of recurrent PTB and reduce the rate of neonatal death.

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