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논문 기본 정보

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학술저널
저자정보
신동욱 (성균관대학교) 조종호 (성균관대학교) 유정은 (서울대학교병원) 조주희 (성균관대학교) 윤동욱 (국군수도병원) 이진희 (성균관대학교) 신수민 (삼성서울병원) 김홍관 (성균관대학교) 최용수 (성균관대학교) 김진국 (성균관대학교) 조재일 (성균관대학교) 심영목 (성균관대학교)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제4호
발행연도
2021.10
수록면
1,057 - 1,071 (15page)
DOI
10.4143/crt.2020.1308

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Purpose Survival probability changes over time in cancer survivors. This study examined conditional survival in patients undergoing curative resection for non-small cell lung cancer (NSCLC). Materials and Methods Five-year conditional recurrence-free survival (CRFS), conditional overall survival (COS), and conditional relative survival (CRS) up to 10 years after surgery were calculated in patients who underwent NSCLC resection from 1994 to 2016. These rates were stratified according to age, sex, year of diagnosis, pathological stage, tumor histology, smoking status, comorbidity, and lung function. Results Five-year CRFS increased from 65.6% at baseline to 90.9% at 10 years after surgery. Early differences in 5-year CRFS according to stratified patient characteristics disappeared, except for age: older patients exhibited persistently lower 5-year CRFS. Five-year COS increased from 72.7% to 78.3% at 8 years and then decreased to 75.4% at 10 years. Five-year CRS increased from 79.0% at baseline to 86.8% at 10 years. Older age and higher pathologic stage were associated with lower 5-year COS and CRS up to 10 years after surgery. Female patients, those with adenocarcinoma histology, non-smokers, patient without comorbidities and had good lung function showed higher COS and CRS. Conclusion CRFS improved over time, but significant risk remained after 5 years. CRS slightly improved over time but did not reach 90%, suggesting significant excess mortality compared to the general population. Age and stage remained significant predictors of conditional survival several years after surgery. Our conditional survival estimates should help clinicians and patients make informed treatment and personal life decisions based on survivorship status.

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