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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 1,035 - 1,041 (7page)
- DOI
- 10.9799/ksfan.2017.30.5.1035
이용수
초록· 키워드
오류제보하기
(-)-Epigallocatechin-3-gallate (EGCG) is a major catechin found in green tea. It is reported that EGCG possesses various health benefits including anti-cancer, antioxidant, anti-diabetes, and anti-obesity. The objective of this study was to investigate the effects of EGCG on adipogenesis via activation of AMP-activated protein kinase (AMPK) pathway in 3T3-L1 preadipocytes. In order to determine the effects of EGCG on adipogenesis, preadipocyte differentiation was induced in the presence or absence of EGCG (0~100 μM) for a period of 6 days. EGCG significantly inhibited fat accumulation and suppressed the expression of adipogenic specific proteins including peroxisome proliferator-activated receptor (PPAR)-γ. Also, EGCG markedly increased the activation of AMPK and acetyl-CoA carboxylase (ACC) and the production of intracellular reactive oxygen species (ROS). However, any pretreatment with a specific AMPK inhibitor, compound C, abolished the inhibitory effects of the EGCG on PPARγ expression. This study suggests that EGCG has anti-adipogenic effects through modulation of the AMPK signaling pathway and therefore, may be a promising antiobesity agent.
Key words: EGCG, AMPK pathway, 3T3-L1 cells, ROS, PPARγ
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Ahmad N / 1999 / Green tea polyphenols and cancer : biologic mechanisms and practical implications / Nutr Rev 57:78~83
Assifi MM / 2005 / AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats / Am J Physiol Endocrinol Metab 289:794~800
Carling D / 2011 / AMPactivated protein kinase : Nature’s energy sensor / Nat Chem Biol 7:512~518
Chan CY / 2011 / (-)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression / Life Sci 89:779~785
최준혁 / 2013 / 참취(Aster scaber Thunb.) 추출물의 항산화 효과와 3T3-L1 지방전구세포에서의 지방분화 억제 효과 / 한국식품과학회지 45(3):356~363
Assifi MM / 2005 / AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats / Am J Physiol Endocrinol Metab 289:794~800
Carling D / 2011 / AMPactivated protein kinase : Nature’s energy sensor / Nat Chem Biol 7:512~518
Chan CY / 2011 / (-)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression / Life Sci 89:779~785
최준혁 / 2013 / 참취(Aster scaber Thunb.) 추출물의 항산화 효과와 3T3-L1 지방전구세포에서의 지방분화 억제 효과 / 한국식품과학회지 45(3):356~363
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