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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 477 - 486 (10page)
- DOI
- https://doi.org/10.9799/ksfan.2021.34.5.477
이용수
초록· 키워드
오류제보하기
To utilize Malus pruniforia Borkh. as a functional material, cold-water (CW), hot-water (HW), and 70% ethanol (EtOH) extracts were prepared, and their antioxidant and anti-inflammatory activities were compared. The antioxidant activity of the HW extract evaluated by ABTS and DPPH radical scavenging and FRAP activity was significantly effective. The total polyphenol content of the HW extract was also higher by 15.5±0.7 mg GAE/g extract compared to other extracts. The EtOH extract showed significantly decreased TNF-α (39.8%), IL-6 (65.5%), and NO (34.9%) levels in RAW 264.7 cells compared to the LPS-induced control group.
The levels of IL-6 (21.1%) and IL-8 (19.3%) were significantly decreased by treatment of EtOH extract in HaCaT keratinocytes induced with TNF-α and IFN-γ. The UHPLC-MS results indicated that the EtOH extract might have chlorogenic acid and phlorizin as the major compounds. This was validated using HPLC-DAD, which showed that the EtOH extract had higher levels of chlorogenic acid and phlorizin (1,185±58 and 470±10 μg/g extract, respectively). In conclusion, the present study suggested that the anti-inflammatory activity of the EtOH extract was more effective than the CW and HW extracts, and chlorogenic acid and phlorizin could be used as indicator compounds and functional substances.
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참고문헌 (29)
참고문헌 신청
방혜열 / 2015 / 후지 사과의 산지에 따른 부위별 항산화 활성 비교 / 한국식품영양과학회지 44(4):557~563
조강희 / 2014 / S-allele Specific PCR 분석에 의한 사과와 꽃사과 품종의 자가불화합성 유전자형 동정 / 한국육종학회지 46(4):364~371
Ha Y / 2020 / Pyropia yezoensis extract suppresses IFN-gamma-and TNF-alpha-induced proinflammatory chemokine production in HaCaT cells via the downregulation of NF-κB / Nutrients 12:1238
Ha YM / 1995 / Selection of new crabapple cultivars as pollinizers for apple orchard / J Korean Soc Hortic Sci 36:281~291
홍정진 / 2021 / 추출방법에 따른 미숙사과 추출물의 유용성분 함량 및 항산화 활성 / 한국식품영양학회지 34(2):174~180
조강희 / 2014 / S-allele Specific PCR 분석에 의한 사과와 꽃사과 품종의 자가불화합성 유전자형 동정 / 한국육종학회지 46(4):364~371
Ha Y / 2020 / Pyropia yezoensis extract suppresses IFN-gamma-and TNF-alpha-induced proinflammatory chemokine production in HaCaT cells via the downregulation of NF-κB / Nutrients 12:1238
Ha YM / 1995 / Selection of new crabapple cultivars as pollinizers for apple orchard / J Korean Soc Hortic Sci 36:281~291
홍정진 / 2021 / 추출방법에 따른 미숙사과 추출물의 유용성분 함량 및 항산화 활성 / 한국식품영양학회지 34(2):174~180
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