지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 845 - 854 (10page)
- DOI
- https://doi.org/10.3803/EnM.2021.1098
이용수
초록· 키워드
오류제보하기
Background: Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease(NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This studyaimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes.
Methods: We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), whichwas defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participantswere classified according to the baseline body mass index and weight difference over 4 years.
Results: On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed asignificantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI],1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR,1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLDcompared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53).
Conclusion: Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable bodyweight.
목차
등록된 정보가 없습니다.
참고문헌 (4)
참고문헌 신청
오지연 / 2007 / 한국어판 단문형 국제신처활동설문(IPAQ)의 신뢰도와 타당도 / Korean Journal of Family Medicine 28(7):532~541
김다혜 / 2020 / Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study / Endocrinology and Metabolism 35(4):933~942
Hill AJ / 2004 / Does dieting make you fat? / Br J Nutr 92(Suppl 1):S15~S18
이은정 / 2011 / The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects / Diabetes and Metabolism Journal 35(2):138~148
김다혜 / 2020 / Variabilities in Weight and Waist Circumference and Risk of Myocardial Infarction, Stroke, and Mortality: A Nationwide Cohort Study / Endocrinology and Metabolism 35(4):933~942
Hill AJ / 2004 / Does dieting make you fat? / Br J Nutr 92(Suppl 1):S15~S18
이은정 / 2011 / The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects / Diabetes and Metabolism Journal 35(2):138~148
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