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논문 기본 정보

자료유형
학술저널
저자정보
정인하 (성균관대학교) 구대정 (창원파티마병원) 이미연 (성균관대학교) 문선준 ((의) 삼성의료재단) 권혜미 (성균관대학교) 박세은 (성균관대학교) 이은정 (성균관대학교) 이원영 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.4
발행연도
2021.8
수록면
845 - 854 (10page)
DOI
https://doi.org/10.3803/EnM.2021.1098

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Background: Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease(NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This studyaimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. Methods: We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), whichwas defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participantswere classified according to the baseline body mass index and weight difference over 4 years. Results: On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed asignificantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI],1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR,1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLDcompared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Conclusion: Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable bodyweight.

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