지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,201 - 1,210 (10page)
- DOI
- https://doi.org/10.3803/EnM.2021.1206
이용수
초록· 키워드
오류제보하기
Background: A decrease in computed tomography (CT)-derived skeletal muscle radiodensity (SMD) reflects age-related ectopic fat infiltration of muscle, compromising muscle function and metabolism. We investigated the age-related trajectory of SMD and its association with vertebral trabecular bone density in healthy adults.
Methods: In a cohort of healthy adult kidney donors aged 19 to 69 years (n=583), skeletal muscle index (SMI, skeletal muscle area/height2), SMD, and visceral-to-subcutaneous fat (V/S) ratio were analyzed at the level of L3 from preoperative CT scans. Low bone mass was defined as an L1 trabecular Hounsfield unit (HU) <160 HU.
Results: L3SMD showed constant decline from the second decade (annual change ?0.38% and ?0.43% in men and women), whereas the decline of L3SMI became evident only after the fourth decade of life (?0.37% and ?0.18% in men and women). One HU decline in L3SMD was associated with elevated odds of low bone mass (adjusted odds ratio, 1.07; 95% confidence interval, 1.02 to 1.13; P=0.003), independent of L3SMI, age, sex, and V/S ratio, with better discriminatory ability compared to L3SMI (area under the receiver-operating characteristics curve 0.68 vs. 0.53, P<0.001). L3SMD improved the identification of low bone mass when added to age, sex, V/S ratio, and L3SMI (category-free net reclassification improvement 0.349, P<0.001; integrated discrimination improvement 0.015, P=0.0165).
Conclusion: L3SMD can be an early marker for age-related musculoskeletal changes showing linear decline throughout life from the second decade in healthy adults, with potential diagnostic value for individuals with low bone mass.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Cruz-Jentoft AJ / 2019 / Sarcopenia : revised European consensus on definition and diagnosis / Age Ageing 48:16~31
World Health Organization / Assessment of fracture risk and its application to screening for postmenopausal osteoporosis:report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]
Goodpaster BH / 2006 / The loss of skeletal muscle strength, mass, and quality in older adults : the health, aging and body composition study / J Gerontol A Biol Sci Med Sci 61:1059~1064
유준일 / 2018 / Review of Epidemiology, Diagnosis, and Treatment of Osteosarcopenia in Korea / 대한골대사학회지 25(1):1~7
탐 다오 / 2020 / Sarcopenia and Muscle Aging: A Brief Overview / Endocrinology and Metabolism 35(4):716~732
World Health Organization / Assessment of fracture risk and its application to screening for postmenopausal osteoporosis:report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]
Goodpaster BH / 2006 / The loss of skeletal muscle strength, mass, and quality in older adults : the health, aging and body composition study / J Gerontol A Biol Sci Med Sci 61:1059~1064
유준일 / 2018 / Review of Epidemiology, Diagnosis, and Treatment of Osteosarcopenia in Korea / 대한골대사학회지 25(1):1~7
탐 다오 / 2020 / Sarcopenia and Muscle Aging: A Brief Overview / Endocrinology and Metabolism 35(4):716~732
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