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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 509 - 519 (11page)
- DOI
- https://doi.org/10.1186/s40824-021-00233-7
이용수
초록· 키워드
오류제보하기
Background: Critical bone defects remain challenges for clinicians, which cannot heal spontaneously and require medical intervention. Following the development of three-dimensional (3D) printing technology is widely used in bone tissue engineering for its outstanding customizability. The 3D printed scaffolds were usually accompanied with growth factors, such as bone morphometric protein 2 (BMP-2), whose effects have been widely investigated on bone regeneration. We previously fabricated and investigated the effect of a polylactic acid (PLA) cage/Biogel scaffold as a carrier of BMP-2. In this study, we furtherly investigated the effect of another shape of PLA cage/Biogel scaffold as a carrier of BMP-2 in a rat calvaria defect model and an ectopic ossification (EO) model. Method: The PLA scaffold was printed with a basic commercial 3D printer, and the PLA scaffold was combined with gelatin and alginate-based Biogel and BMP-2 to induce bone regeneration. The experimental groups were divided into PLA scaffold, PLA scaffold with Biogel, PLA scaffold filled with BMP-2, and PLA scaffold with Biogel and BMP-2 and were tested both in vitro and in vivo. One-way ANOVA with Bonferroni post-hoc analysis was used to determine whether statistically significant difference exists between groups. Result: The in vitro results showed the cage/Biogel scaffold released BMP-2 with an initial burst release and followed by a sustained slow-release pattern. The released BMP-2 maintained its osteoinductivity for at least 14 days. The in vivo results showed the cage/Biogel/BMP-2 group had the highest bone regeneration in the rat calvarial defect model and EO model. Especially, the bone regenerated more regularly in the EO model at the implanted sites, which indicated the cage/Biogel had an outstanding ability to control the shape of regenerated bone. Conclusion: In conclusion, the 3D printed PLA cage/Biogel scaffold system was proved to be a proper carrier for BMP 2 that induced significant bone regeneration and induced bone formation following the designed shape.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Aho AJ / 1994 / Incorporation and clinical results of large allografts of the extremities and pelvis / Clin Orthop Relat Res 307:200~213
Beier JP / 2010 / Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model / J Tissue Eng Regen Med 4(3):216~223
Murata Koichi / 2020 / Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite / Asian Spine Journal 14(6):808~813
Zhang Y / 2020 / Three-dimensionalprinted customized prosthesis for pubic defect: prosthesis design and surgical techniques
Yeo A / 2008 / Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions / J Biomed Mater Res B Appl Biomater 87(2):562~569
Beier JP / 2010 / Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model / J Tissue Eng Regen Med 4(3):216~223
Murata Koichi / 2020 / Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite / Asian Spine Journal 14(6):808~813
Zhang Y / 2020 / Three-dimensionalprinted customized prosthesis for pubic defect: prosthesis design and surgical techniques
Yeo A / 2008 / Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions / J Biomed Mater Res B Appl Biomater 87(2):562~569
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