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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Biomaterial-based bone tissue engineering represents a promising solution to overcome reduced residual bone volume. It has been previously demonstrated that gradient and offset architectures of threedimensional melt electrowritten poly-caprolactone (PCL) scaffolds could successfully direct osteoblast cells differentiation toward an osteogenic lineage, resulting in mineralization. The aim of this study was therefore to evaluate the in vivo osteoconductive capacity of PCL scaffolds with these different architectures. Methods: Five different calcium phosphate (CaP) coated melt electrowritten PCL pore sized scaffolds: 250 μm and 500 μm, 500 μm with 50% fibre offset (offset.50.50), tri layer gradient 250?500-750 μm (grad.250top) and 750?500-250 μm (grad.750top) were implanted into rodent critical-sized calvarial defects. Empty defects were used as a control. After 4 and 8 weeks of healing, the new bone was assessed by micro-computed tomography and immunohistochemistry. Results: Significantly more newly formed bone was shown in the grad.250top scaffold 8 weeks postimplantation. Histological investigation also showed that soft tissue was replaced with newly formed bone and fully covered the grad.250top scaffold. While, the bone healing did not happen completely in the 250 μm, offset.50.50 scaffolds and blank calvaria defects following 8 weeks of implantation. Immunohistochemical analysis showed the expression of osteogenic markers was present in all scaffold groups at both time points. The mineralization marker Osteocalcin was detected with the highest intensity in the grad.250top and 500 μm scaffolds. Moreover, the expression of the endothelial markers showed that robust angiogenesis was involved in the repair process. Conclusions: These results suggest that the gradient pore size structure provides superior conditions for bone regeneration.
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참고문헌 (82)
참고문헌 신청
Tao O / 2019 / The applications of 3D printing for craniofacial tissue engineering / Micromachines-Basel 10(7):480
Rohman G / 2019 / The use of platelet-rich plasma to promote cell recruitment into lowmolecular-weight Fucoidan-functionalized poly(Ester-urea-urethane)scaffolds for soft-tissue engineering / Polymers-Basel 11(6):1016
Barati D / 2019 / Material and regenerative properties of an osteon-mimetic cortical bone-like scaffold / Regen Biomater 6(2):89~98
Chocholata P / 2019 / Fabrication of scaffolds for bone-tissue regeneration / Materials 12(4):568
Woodruff MA / 2010 / The return of a forgotten polymer-Polycaprolactone in the 21st century / Prog Polym Sci 35(10):1217~1256
Rohman G / 2019 / The use of platelet-rich plasma to promote cell recruitment into lowmolecular-weight Fucoidan-functionalized poly(Ester-urea-urethane)scaffolds for soft-tissue engineering / Polymers-Basel 11(6):1016
Barati D / 2019 / Material and regenerative properties of an osteon-mimetic cortical bone-like scaffold / Regen Biomater 6(2):89~98
Chocholata P / 2019 / Fabrication of scaffolds for bone-tissue regeneration / Materials 12(4):568
Woodruff MA / 2010 / The return of a forgotten polymer-Polycaprolactone in the 21st century / Prog Polym Sci 35(10):1217~1256
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