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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,652 - 1,658 (7page)
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초록· 키워드
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Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia. This study investigated gray and white matter changes in the brains of SMI patients compared with normal controls and mild cognitive impairment (MCI) patients. We recruited 28 normal controls, 28 subjects with SMI, and 29 patients with MCI aged 60 or older. We analyzed gray and white matter changes using a voxel-based morphometry (VBM), hippocampal volumetry and regions of interest in diffusion tensor imaging (DTI). DTI parameters of corpus callosum and cingulum in SMI showed more white matter changes compared with those in normal controls, they were similar to those in MCI except in the hippocampus, which showed more degenerations in MCI. In VBM, SMI showed atrophy in the frontal, temporal, and parietal lobes compared with normal controls although it was not as extensive as that in MCI. Patients with SMI showed gray and white matter degenerations, the changes were distinct in white matter structures. SMI might be the first presenting symptom within the Alzheimer’s disease continuum when combined with additional risk factors and neurodegenerative changes.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
van Oijen M / 2007 / Subjective memory complaints, education, and risk of Alzheimer’s disease / Alzheimers Dement 3:92~97
Scheef L / 2012 / Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment / Neurology 79:1332~1339
Mosconi L / 2008 / Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints / Biol Psychiatry 63:609~618
Selnes P / 2012 / White matter imaging changes in subjective and mild cognitive impairment / Alzheimers Dement 8:S112~S121
Le Bihan D / 2001 / Diffusion tensor imaging : concepts and applications / J Magn Reson Imaging 13:534~546
Scheef L / 2012 / Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment / Neurology 79:1332~1339
Mosconi L / 2008 / Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints / Biol Psychiatry 63:609~618
Selnes P / 2012 / White matter imaging changes in subjective and mild cognitive impairment / Alzheimers Dement 8:S112~S121
Le Bihan D / 2001 / Diffusion tensor imaging : concepts and applications / J Magn Reson Imaging 13:534~546
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