지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 471 - 482 (12page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.471
이용수
초록· 키워드
오류제보하기
Objective: Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes.
However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD.
Methods: Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions.
Results: UD exhibited differences from controls for DKI measures and CBF in the left putamen and caudate. BD showed differences from controls for DKI measures in the left caudate. Additionally, BD showed lower Ka in right putamen, higher MD in right caudate compared with UD. Receiver operating characteristic analysis revealed the Kr of left caudate had the highest predictive power for distinguishing UD from controls.
Conclusion: The two disorders may have overlaps in microstructural abnormality in basal ganglia. The change of caudate may serve as a potential biomarker for UD.
목차
등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Judd LL / 2002 / The long-term natural history of the weekly symptomatic status of bipolar I disorder / Arch Gen Psychiatry 59:530~537
Hirschfeld RM / 2003 / Perceptions and impact of bipolar disorder : how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder / J Clin Psychiatry 64:161~174
Rubio JM / 2011 / Epidemiology of chronic and nonchronic major depressive disorder : results from the national epidemiologic survey on alcohol and related conditions / Depress Anxiety 28:622~631
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Kempton MJ / 2011 / Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder / Arch Gen Psychiatry 68:675~690
Hirschfeld RM / 2003 / Perceptions and impact of bipolar disorder : how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder / J Clin Psychiatry 64:161~174
Rubio JM / 2011 / Epidemiology of chronic and nonchronic major depressive disorder : results from the national epidemiologic survey on alcohol and related conditions / Depress Anxiety 28:622~631
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Kempton MJ / 2011 / Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder / Arch Gen Psychiatry 68:675~690
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