지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 273 - 280 (8page)
- DOI
- https://doi.org/10.3988/jcn.2017.13.3.273
이용수
초록· 키워드
오류제보하기
Background and Purpose The quality of anticoagulation is critical for ensuring the benefit of warfarin, but this has been less well studied in Korean ischemic stroke patients with atrial fibrillation (AF).
Methods This study retrospectively analyzed the data of patients who had an AF-related ischemic stroke and were treated with long-term warfarin therapy in 16 Korean centers. The quality of warfarin therapy was primarily assessed by the time in therapeutic range [TTR; international normalized ratio (INR), 2.0?3.0] and additionally by the proportion of INR values within the therapeutic range.
Results The long-term warfarin-treated cohort comprised 1,230 patients. They were aged 70.1±9.7 years (mean±SD), 42.5% were female, and their CHA2DS2-VASc score was 4.75±1.41.
The TTR analysis included 33,941 INR measurements for 27,487 months: per patients, 27.6 (SD, 22.4) INR measurements for 22.4 (SD, 12.9) months. The mean TTR of individual patients was 49.1% (95% confidence interval, 47.9?50.3%), and the TTR quartiles were <34.5, 34.5?49.1, 49.1? 64.5%, and >64.5%. None of the 16 centers achieved a mean TTR of >60%. Of all INR measurements, 44.6% were within the therapeutic range, 41.7% were <2.0, and 13.7% were >3.0.
Conclusions In Korean ischemic stroke patients who had AF, the quality of warfarin therapy was low and might be inadequate to effectively prevent recurrent stroke or systemic embolism.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Jung KH / 2012 / Secular trends in ischemic stroke characteristics in a rapidly developed country:results from the Korean Stroke Registry Study (secular trends in Korean stroke) / Circ Cardiovasc Qual Outcomes 5:327~334
김범준 / 2015 / Case Characteristics, Hyperacute Treatment, and Outcome Information from the Clinical Research Center for Stroke-Fifth Division Registry in South Korea / 대한뇌졸중학회지 17(1):38~53
Jones M / 2005 / Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with nonvalvar atrial fibrillation: a record linkage study in a large British population / Heart 91:472~477
Gallagher AM / 2011 / Risks of stroke and mortality associated with suboptimal anticoagulation in atrial fibrillation patients / Thromb Haemost 106:968~977
김은수 / 2013 / Estimation of vitamin K intake in Koreans and determination of the primary vitamin K-containing food sources based on the fifth Korean National Health and Nutrition Examination Survey (2010-2011) / Nutrition Research and Practice 7(6):503~509
김범준 / 2015 / Case Characteristics, Hyperacute Treatment, and Outcome Information from the Clinical Research Center for Stroke-Fifth Division Registry in South Korea / 대한뇌졸중학회지 17(1):38~53
Jones M / 2005 / Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with nonvalvar atrial fibrillation: a record linkage study in a large British population / Heart 91:472~477
Gallagher AM / 2011 / Risks of stroke and mortality associated with suboptimal anticoagulation in atrial fibrillation patients / Thromb Haemost 106:968~977
김은수 / 2013 / Estimation of vitamin K intake in Koreans and determination of the primary vitamin K-containing food sources based on the fifth Korean National Health and Nutrition Examination Survey (2010-2011) / Nutrition Research and Practice 7(6):503~509
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