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논문 기본 정보

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학술저널
저자정보
Ertugrul Erhan (Erzincan University) Suat Terzi (Recep Tayyip Erdogan University) Metin Celiker (Rize Education and Research Hospital) Oguzhan Yarali (Erzurum Training and Research Hospital) Murat Cankaya (Erzincan University) Ferda Keskin Cimen (Mengucek Gazi Education and Research Hospital) Ismail Malkoc (Ataturk University) Bahadir Suleyman (Erzincan University)
저널정보
대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제10권 제2호
발행연도
2017.6
수록면
181 - 187 (7page)
DOI
http://dx.doi.org/10.21053/ceo.2016.00262

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Objectives. The objective of this study is to investigate and evaluate the effect of Hippophae rhamnoides extract (HRE) on oropharyngeal mucositis induced in rats with methotrexate (MTX) through biochemical, gene expression, and histopathological examinations. Methods. Experimental animals were divided into a healthy group (HG), a HRE+MTX (HREM) group, HRE group (HREG), and a control group that received MTX (MTXG). The HREM and HREG groups of rats was administered 50 mg/kg HRE, while the MTXG and HG groups were given an equal volume distilled water with gavage. Then, the HREM and MTXG rat groups were given oral MTX at a dose of 5 mg/kg 1 hour after HRE and distilled water was administered. This procedure was repeated for 1 month. At the end of this period, all of the animals were sacrificed with a high dose of anesthesia. Then, the amounts of malondialdehyde (MDA) and total glutathione (tGSH) were determined in the removed oropharyngeal tissues. Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) gene expressions were measured, and all the tissues were studied histopathologically. Results. The amount of MDA was significantly increased in the MTXG group compared to the HREM, HREG, and HG groups (P<0.001). MTX significantly decreased the amount of tGSH in the MTXG group compared to the HREM, HREG, and HG groups (P<0.001). In this study, there were no visible ulcers in the animal group in which the levels of MDA, IL-1β, and TNF-α were high and the level of tGSH was low. However, histopathologic examination revealed mucin pools in wide areas due to ruptured oropharynx glands, and proliferated, dilated, and congested blood vessels and dilated ductal structures in some areas. Conclusion. HRE protected oropharyngeal oxidative damage induced by MTX. As an inexpensive and natural product, HRE has important advantages in the prevention of oropharyngeal damage induced by MTX.
#Methotrexate #Gene Expression #Hippophae #Rhamnoides #Oral Mucositis #Rat

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참고문헌 (31)

참고문헌 신청
Kwong KK / 2004 / Prevention and treatment of oropharyngeal mucositis following cancer therapy: are there new approaches? / Cancer Nurs 27(3):183~205 google schola Weisdorf DJ / 1989 / Oropharyngeal mucositis complicating bone marrow transplantation: prognostic factors and the effect of chlorhexidine mouth rinse / Bone Marrow Transplant 4(1):89~95 google schola Sonis ST. / 2009 / Mucositis: the impact, biology and therapeutic opportunities of oral mucositis / Oral Oncol 45(12):1015~1020 google schola Scully C / 2003 / Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis / Head Neck 25(12):1057~1070 google schola Ahmed KM. / 2013 / The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer: a randomized clinical trial / Saudi Dent J 25(4):141~147 google schola

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