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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,589 - 1,596 (8page)
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The purpose of this study was to evaluate the effects of rheumatoid arthritis (RA) and antirheumatic drugs on atherosclerosis by comparing carotid intima-media thickness (CIMT) as an indicator for cardiovascular diseases (CVD). This study included 44 female RA patients who met the 2010 ACR/EULAR criteria and age-matched 22 healthy females. CIMT was measured on both carotid arteries using a B-mode ultrasound scan. The mean value of both sides was taken as the CIMT of the subject. The CIMT was evaluated according to the use of drugs, disease activity and CVD risk factors in RA patients as a case-control study. Higher CIMT was observed in RA patients as compared with healthy subjects (0.705 ± 0.198 mm, 0.611 ± 0.093 mm, respectively, P < 0.05). With adjustment for the CVD risk factors, disease activity and the use of anti-rheumatic drugs, methotrexate (MTX) only showed a favorable effect on CIMT in RA. A significantly lower CIMT was observed in RA with MTX as compared with RA without MTX (0.644 ± 0.136 mm, 0.767 ± 0.233 mm, respectively, P < 0.05). The effects were correlated with MTX dosage (β = -0.029, P < 0.01). The use of MTX should be considered in high priority not only to control arthritis but also to reduce the RA-related CVD risk to mortality.
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참고문헌 (33)
참고문헌 신청
Watson DJ / 2003 / All-cause mortality and vascular events among patients with rheumatoid arthritis, osteoarthritis, or no arthritis in the UK General Practice Research Database / J Rheumatol 30:1196~1202
Bacon PA / 2002 / Accelerated atherogenesis in autoimmune rheumatic diseases / Autoimmun Rev 1:338~347
Corrales A / 2015 / Carotid artery plaque in women with rheumatoid arthritis and low estimated cardiovascular disease risk : a crosssectional study / Arthritis Res Ther 17:55
Naz SM / 2007 / Mortality in established rheumatoid arthritis / Best Pract Res Clin Rheumatol 21:871~883
Gasparyan AY / 2010 / The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases / Curr Vasc Pharmacol 8:437~449
Bacon PA / 2002 / Accelerated atherogenesis in autoimmune rheumatic diseases / Autoimmun Rev 1:338~347
Corrales A / 2015 / Carotid artery plaque in women with rheumatoid arthritis and low estimated cardiovascular disease risk : a crosssectional study / Arthritis Res Ther 17:55
Naz SM / 2007 / Mortality in established rheumatoid arthritis / Best Pract Res Clin Rheumatol 21:871~883
Gasparyan AY / 2010 / The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases / Curr Vasc Pharmacol 8:437~449
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