Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

Aida Doostkam; Hossein Mirkhani; Kamyar Iravani; Saied Karbalay-Doust; Kazem Zarei

doi:https://doi.org/10.21053/ceo.2019.02068

추천

검색

자료유형: 학술저널

저자정보: Aida Doostkam (Shiraz University of Medical Sciences) Hossein Mirkhani (Shiraz University of Medical Sciences) Kamyar Iravani (Shiraz University of Medical Sciences) Saied Karbalay-Doust (Shiraz University of Medical Sciences) Kazem Zarei (Shiraz University of Medical Sciences)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제3호

발행연도: 2021.8

수록면: 259 - 267 (9page)

DOI: https://doi.org/10.21053/ceo.2019.02068

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model. Methods. Forty Sprague-Dawley rats were randomly assigned to the following groups: group 1, control; group 2, diabetic rats; and groups 3?5, rats treated with rutin (at doses of 50, 100, and 150 mg/kg, respectively). We used auditory brain stem response, stereology of the spiral ganglion, and measurements of superoxide dismutase (SOD) and malondialdehyde (MDA) to evaluate the effects of treatment. Results. Significant improvements in auditory neuropathy were observed in the rutin-treated groups in comparison with the diabetic group (P<0.05). Auditory threshold, wave latency, wave morphology, the volume and number of neurons in the spiral ganglion, and SOD and MDA activity showed improvements following treatment. Conclusion. Rutin shows promise as a treatment modality for diabetic auditory neuropathy, but more trials are warranted for its clinical application.

#Diabetic Neuropathy #Rutin #Histology #Auditory Brainstem Response #Animal Model

참고문헌 (34)

참고문헌 신청

Tousoulis D / 2013 / Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches / J Am Coll Cardiol 62(8):667~676

Kampoli AM / 2011 / Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus / Curr Pharm Des 17(37):4147~4158

Asmat U / 2016 / Diabetes mellitus and oxidative stress-A concise review / Saudi Pharm J 24(5):547~553

Feldman EL / 2017 / New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain / Neuron 93(6):1296~1313

Ozougwu JC / 2013 / The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus / J Physiol Pathophysiol 4(4):46~57

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!