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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 827 - 840 (14page)
- DOI
- 10.5009/gnl20367
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초록· 키워드
오류제보하기
Nonalcoholic fatty liver disease (NAFLD) patients with diabetes constitute a subgroup of patients with a high rate of liver-related complications. Currently, there are no specific drug recommendations for these patients. Metformin, a conventional insulin sensitizer agent, has been widely prescribed in patients with diabetes. Metformin treatment has been shown to be effective at alleviating hepatic lipogenesis in animal models of NAFLD, with a variety of mechanisms being deemed responsible. To date, most studies have enrolled diabetic patients who are treated with metformin, with the drug being taken continuously throughout the study. Although evidence exists regarding the benefits of metformin for NAFLD in preclinical studies, reports on the efficacy of metformin in adult NAFLD patients have had some discrepancies regarding changes in liver biochemistry and hepatic fat content. Evidence has also suggested possible effects of metformin as regards the prevention of hepatocellular carcinoma tumorigenesis. This review was performed to comprehensively summarize the available in vitro, in vivo and clinical studies regarding the effects of metformin on liver steatosis for the treatment of adult NAFLD patients with diabetes. Consistent reports as well as controversial findings are included in this review, and the mechanistic insights are also provided. In addition, this review focuses on the efficacy of metformin as a monotherapy and as a combined therapy with other antidiabetic medications.
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등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Allen AM / 2018 / Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death : a 20 year-community study / Hepatology 67:1726~1736
Sanyal AJ / 2001 / Nonalcoholic steatohepatitis : association of insulin resistance and mitochondrial abnormalities / Gastroenterology 120:1183~1192
Williams CD / 2011 / Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy : a prospective study / Gastroenterology 140:124~131
Lomonaco R / 2016 / Metabolic impact of nonalcoholic steatohepatitis in obese patients with type 2 diabetes / Diabetes Care 39:632~638
Rena G / 2017 / The mechanisms of action of metformin / Diabetologia 60:1577~1585
Sanyal AJ / 2001 / Nonalcoholic steatohepatitis : association of insulin resistance and mitochondrial abnormalities / Gastroenterology 120:1183~1192
Williams CD / 2011 / Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy : a prospective study / Gastroenterology 140:124~131
Lomonaco R / 2016 / Metabolic impact of nonalcoholic steatohepatitis in obese patients with type 2 diabetes / Diabetes Care 39:632~638
Rena G / 2017 / The mechanisms of action of metformin / Diabetologia 60:1577~1585
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