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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: Recent evidence shows that the quantitative value of amyloid-beta (Aβ) deposition below the threshold of Aβ positivity carries biological and clinical significance regarding future cognitive decline. We evaluated whether the quantitative value of subthreshold Aβ deposition had a significant correlation with neuropsychological test scores in cognitively normal older adults without the APOE ε4 allele.
Methods: Sixty cognitively normal APOE ε4 allele non-carriers with negative Aβ retention aged 60 to 85 years were included in this study. We assessed neuropsychological performance with the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) and obtained standardized [18F] flutemetamol uptake values in the pons as a reference (SUVRPONS), evaluated with PET. Multiple regression analyses were conducted to assess the effect of global and regional Aβ load on cognitive performance, adjusting for age, sex, years of education, and volumes of white matter hyperintensities.
Results: We found that Aβ deposition in the precuneus, posterior cingulate cortex, and parietal lobe had a significant association with the total CERAD-K scores. There was also a significant correlation between the SUVRPONS in the precuneus and the CERAD-K total score after Bonferroni correction.
Conclusion: Subthreshold Aβ retention in the core brain regions of the default mode network could affect cognitive functions in the cognitively normal APOE ε4 non-carriers, considered to be the lowest risk group for Alzheimer’s disease (AD).
목차
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참고문헌 (50)
참고문헌 신청
World Health Organization / Global action plan on the public health response to dementia 2017–2025
Prince M / 2015 / World Alzheimer Report 2015. The global impact of dementia: an analysis of prevalence, incidence, cost and trends
Sperling R / 2014 / The evolution of preclinical Alzheimer’s disease : implications for prevention trials / Neuron 84:608~622
Twamley EW / 2006 / Neuropsychological and neuroimaging changes in preclinical Alzheimer’s disease / J Int Neuropsychol Soc 12:707~735
Sperling RA / 2013 / Preclinical Alzheimer disease—the challenges ahead / Nat Rev Neurol 9:54~58
Prince M / 2015 / World Alzheimer Report 2015. The global impact of dementia: an analysis of prevalence, incidence, cost and trends
Sperling R / 2014 / The evolution of preclinical Alzheimer’s disease : implications for prevention trials / Neuron 84:608~622
Twamley EW / 2006 / Neuropsychological and neuroimaging changes in preclinical Alzheimer’s disease / J Int Neuropsychol Soc 12:707~735
Sperling RA / 2013 / Preclinical Alzheimer disease—the challenges ahead / Nat Rev Neurol 9:54~58
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