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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 37 - 46 (10page)
- DOI
- 10.35607/kjoa.42.1.202112.004
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초록· 키워드
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Odontogenic ameloblast-associated protein (ODAM) reportedly plays an important role in maintaining periodontal integrity. We aimed to investigate the cause of different ODAM values in the gingival crevicular fluid (GCF) and discrepancies between GCF ODAM values and histological ODAM distribution in periodontal disease. ODAM concentration in the GCF of nine adult patients with severe periodontitis and ODAM distribution in the gingival tissues of three adult patients were analyzed using enzyme-linked immunosorbent assay and immunohistochemistry (IHC), respectively. ODAM in the GCF was detected in six samples but not in the remaining three samples; no differences were observed in the clinical characteristics between the ODAM-positive and ODAM-negative groups. ODAM was observed in the junctional epithelium of healthy gingival tissue by IHC analyses. There were two different ODAM expression patterns in gingival tissues with periodontitis of similar clinical severities, no overall expression or localized overexpression in the connective tissue layer.
ODAM in severe periodontitis was secreted into the GCF or otherwise released into the connective tissue. Although clinically diagnosed as the same degree of periodontitis, the expression pattern of ODAM may differ according to whether ODAM can function as a junctional protein.
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참고문헌 (24)
참고문헌 신청
Nishio C / 2010 / Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional epithelium / European Cells and Materials 20:393~402
Wazen RM / 2015 / Inactivation of the Odontogenic ameloblast-associated gene affects the integrity of the junctional epithelium and gingival healing / European Cells and Materials 30:187~199
Lee HK / 2015 / Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling / J Biol Chem 290(23):14740~14753
Kawasaki K / 2011 / The SCPP gene family and the complexity of hard tissues in vertebrates / Cells Tissues Organs 194(2-4):108~112
Park JC / 2007 / The amyloid protein APin is highly expressed during enamel mineralization and maturation in rat incisors / Eur J Oral Sci 115(2):153~160
Wazen RM / 2015 / Inactivation of the Odontogenic ameloblast-associated gene affects the integrity of the junctional epithelium and gingival healing / European Cells and Materials 30:187~199
Lee HK / 2015 / Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling / J Biol Chem 290(23):14740~14753
Kawasaki K / 2011 / The SCPP gene family and the complexity of hard tissues in vertebrates / Cells Tissues Organs 194(2-4):108~112
Park JC / 2007 / The amyloid protein APin is highly expressed during enamel mineralization and maturation in rat incisors / Eur J Oral Sci 115(2):153~160
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