Effect of Poloxamer-Based Thermo-Sensitive Sol-Gel Agent on Upper Limb Dysfunction after Axillary Lymph Node Dissection: A Double-Blind Randomized Clinical Trial

최희준; 유재민; 채병주; 김은규; 민준원; 신혁재; 남석진; 유종한; 이정언; 이세경; 김석원

doi:10.4048/jbc.2021.24.e30

추천

검색

자료유형: 학술저널

저자정보: 최희준 (Department of Surgery Samsung Changwon Hospital Sungkyunkwan University School of Medicine Changw) 유재민 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 채병주 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 김은규 (Division of Breast Surgery Department of Surgery University Bundang Hospital Seoul National Univers) 민준원 (4Department of Surgery Dankook University College of Medicine Cheonan Korea) 신혁재 (Department of General Surgery Myongji Hospital Goyang Korea.) 남석진 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 유종한 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 이정언 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 이세경 (Division of Breast Surgery Department of Surgery Samsung Medical Center Sungkyunkwan University Sch) 김석원 (성균관대학교)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.24 No.4

발행연도: 2021.8

수록면: 367 - 376 (10page)

DOI: 10.4048/jbc.2021.24.e30

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Restricted shoulder motion is a major morbidity associated with a lower quality of life and disability after axillary lymph node dissection (ALND) in patients with breast cancer. This study sought to evaluate the antiadhesive effect of a poloxamer-based thermosensitive sol-gel (PTAS) agent after ALND. Methods: We designed a double-blind, multicenter randomized controlled study to evaluate the clinical efficacy and safety of PTAS in reducing upper-limb dysfunction after ALND. The primary outcome was the change in the range of motion (ROM) of the shoulder before surgery and 4 weeks after ALND (early postoperative period). Secondary outcomes were shoulder ROM at six months, axillary web syndrome, and lymphedema (late postoperative period). Results: A total of 170 patients with planned ALND were randomly assigned to one of 2 groups (poloxamer and control) and 15 patients were excluded. In the poloxamer group (n = 76), PTAS was applied to the surface of the operative field after ALND. ALND was performed without the use of poloxamer in the control group (n = 79). Relative to the control group, the poloxamer group had significantly lower early postoperative restrictions in total shoulder ROM at four weeks (?30.04 ± 27.76 vs. ?42.59 ± 36.79; p = 0.0236). In particular, the poloxamer group showed greater reductions in horizontal abduction at four weeks (?3.92 ± 9.80 vs. ?10.25 ± 15.42; p = 0.0050). The ROM of the shoulder at 24 weeks, axillary web syndrome, and lymphedema were not significantly different between the two groups. No adverse effects were observed in either group. Conclusion: We suggest that poloxamer might improve the early postoperative shoulder ROM in patients with breast cancer who have undergone ALND.

#Dissection #Poloxamer #Shoulder

참고문헌 (3)

참고문헌 신청

신혜영 / 2018 / Clinical Results of Anti-adhesion Adjuvants after Endonasal Dacryocystorhinostomy / Korean Journal of Ophthalmology 32(6):433~437

이새별 / 2018 / Chronological Improvement in Survival of Patients with Breast Cancer: A Large-Scale, Single-Center Study / Journal of Breast Cancer 21(1):70~79

강상율 / 2018 / Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry / Journal of Breast Cancer 21(1):1~10

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최희준

소속기관 Department of Surgery Samsung Changwon Hospital Sungkyunkwan University School of Medicine Changw