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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 455 - 462 (8page)
- DOI
- 10.4048/jbc.2021.24.e44
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초록· 키워드
오류제보하기
Purpose The breast cancer susceptibility gene, BRCA1, is involved in normal development and carcinogenesis of mammary glands. Here, we aimed to evaluate the relationship between histological findings of mammary gland development and breast cancer risk in BRCA1 mutant mice.
Methods Five BRCA1 mutant mice and five non-mutant FVB/NJ mice were used for each group of 1-month-old (pubertal), 3-month-old (fertile), and 8-month-old (menopausal) mice. In another experiment, 15 BRCA1 mutant mice were followed up to 8 months after birth and classified into tumor-bearing (11 mice) and tumor-free (4 mice) groups. Excised mammary gland tissues were stained with Carmine Alum, and the number of terminal end buds (or alveolar buds), branching density, and duct elongation were measured using image analysis programs. Differences between the two groups were assessed using paired t-test.
Results One-month-old BRCA1 mutant mice showed a higher number of terminal end buds (23.8 ± 1.0 vs. 15.6 ± 0.8, p = 0.0002), branching density (11.7 ± 0.4 vs. 9.6 ± 0.5%, p = 0.0082), and duct elongation (9.7 ± 0.7 vs. 7.3 ± 0.4 mm, p = 0.0186) than controls. However, there was no difference between the 3- and 8-month-old groups. In BRCA1 mutant mice, the tumor-bearing group showed a significantly higher number of alveolar buds (142.7 ± 5.5 vs. 105.5 ± 5.4, p = 0.0008) and branching density (30.0 ± 1.0 vs. 24.1 ± 1.1%, p = 0.008) than the tumor-free group; however, duct elongation was not different (23.9 ± 0.6 vs. 23.6 ± 0.6 mm, p = 0.8099) between the groups.
Conclusion BRCA1 mutant mice exhibited early pubertal mammary gland development and delayed age-related mammary gland involution was associated with breast cancer. Our results may have clinical implications for predicting breast cancer risk and developing prevention strategies for BRCA1 mutation carriers
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Kuchenbaecker KB / 2017 / Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers / JAMA 317:2402~2416
Narod SA / 2006 / Modifiers of risk of hereditary breast cancer / Oncogene 25:5832~5836
Atchley DP / 2008 / Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer / J Clin Oncol 26:4282~4288
Hall JM / 1990 / Linkage of early-onset familial breast cancer to chromosome 17q21 / Science 250:1684~1689
Drost RM / 2009 / Preclinical mouse models for BRCA1-associated breast cancer / Br J Cancer 101:1651~1657
Narod SA / 2006 / Modifiers of risk of hereditary breast cancer / Oncogene 25:5832~5836
Atchley DP / 2008 / Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer / J Clin Oncol 26:4282~4288
Hall JM / 1990 / Linkage of early-onset familial breast cancer to chromosome 17q21 / Science 250:1684~1689
Drost RM / 2009 / Preclinical mouse models for BRCA1-associated breast cancer / Br J Cancer 101:1651~1657
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