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논문 기본 정보

자료유형
학술저널
저자정보
Jaewoo Hong (Daegu Catholic University School of Medicine) Hyunjhung Jhun (Korea Food Research Institute) Yeo-Ok Choi (Konkuk University) Afeisha S. Taitt (Konkuk University) Suyoung Bae (Ministry of Food and Drug Safety) Youngmin Lee (Inje University) Chang-seon Song (Konkuk University) Su Cheong Yeom (Seoul National University) Soohyun Kim (Konkuk University)
저널정보
대한면역학회 Immune Network Immune Network Vol.21 No.1
발행연도
2021.2
수록면
119 - 135 (17page)

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초록· 키워드

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The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is a novel virus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of December 2020, there have been 80.2 million confirmed patients, and the mortality rate is known as 2.16% globally. A strategy to protect a host from SARS-CoV-2 is by suppressing intracellular viral replication or preventing viral entry. We focused on the spike glycoprotein that is responsible for the entry of SARS-CoV-2 into the host cell. Recently, the US Food and Drug Administration/EU Medicines Agency authorized a vaccine and antibody to treat COVID-19 patients by emergency use approval in the absence of long-term clinical trials. Both commercial and academic efforts to develop preventive and therapeutic agents continue all over the world. In this review, we present a perspective on current reports about the spike glycoprotein of SARS-CoV-2 as a therapeutic target.

목차

ABSTRACT
INTRODUCTION
STRUCTURE OF S GLYCOPROTEIN
AN ENZYME RESPONSIBLE FOR S GLYCOPROTEIN S CLEAVAGE SITE
S1 AND S2 SUBUNIT FUNCTION IN INFECTION
MUTATION OF S GLYCOPROTEIN IN INFECTIVITY ANDIMMUNOGENICITY
ATTACHMENT OF S GLYCOPROTEIN
Ab AND SOLUBLE RECEPTOR THERAPY
A STRATEGY FOR TARGETING S1 AND S2 SEPARATELY
CONCLUSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2021-517-001563513