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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한뇌혈관외과학회 Journal of Cerebrovascular and Endovascular Neurosurgery Journal of Cerebrovascular and Endovascular Neurosurgery Vol.23 No.4
- 발행연도
- 2021.12
- 수록면
- 304 - 313 (10page)
- DOI
- 10.7461/jcen.2021.E2021.04.003
이용수
초록· 키워드
오류제보하기
Objective: Macrophages have been shown to play important roles in various pathophysiological processes of the central nervous system via neuroinflammation, leading to an increased interest in macrophage biology. Circulating blood monocytes are among the first cells to infiltrate the brain after ischemic stroke; however, the role of innate immune cells such as monocytes and macrophages remains to be elucidated. Here, we investigated the association between blood monocytes and infarct size following ischemic stroke.
Methods: We induced stroke using a focal ischemia mouse model through middle cerebral artery suture occlusion. To deplete circulating blood monocytes, clodronate was injected intraperitoneally 24 h before the surgery. Animals were sacrificed at specified time points, and the infarct size and mRNA expression were then measured.
Results: The clodronate-injected mice showed significantly smaller infarct size than the control mice. Immunohistochemical staining revealed that monocyte depletion significantly blocked the infiltration of macrophages and microglia. The mRNA expression levels of macrophage and microglia markers were higher in the left infarcted brain than in the right non-infarcted brain.
Conclusions: In summary, monocyte depletion reduced the infarct size and mitigated neurological deficits in mice following ischemic stroke, likely by blocking the infiltration of inflammatory cells such as macrophages and microglia.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Bennett ML / 2016 / New tools for studying microglia in the mouse and human CNS / Proc Natl Acad Sci U S A 113(12):E1738~E1746
Chiba T / 2013 / Pivotal roles of monocytes/macrophages in stroke / Mediators Inflamm 2013:759103
Durukan A / 2007 / Acute ischemic stroke : overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia / Pharmacol Biochem Behav 87(1):179~197
Gelderblom M / 2009 / Temporal and spatial dynamics of cerebral immune cell accumulation in stroke / Stroke 40(5):1849~1857
Gliem M / 2012 / Macrophages prevent hemorrhagic infarct transformation in murine stroke models / Ann Neurol 71(6):743~752
Chiba T / 2013 / Pivotal roles of monocytes/macrophages in stroke / Mediators Inflamm 2013:759103
Durukan A / 2007 / Acute ischemic stroke : overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia / Pharmacol Biochem Behav 87(1):179~197
Gelderblom M / 2009 / Temporal and spatial dynamics of cerebral immune cell accumulation in stroke / Stroke 40(5):1849~1857
Gliem M / 2012 / Macrophages prevent hemorrhagic infarct transformation in murine stroke models / Ann Neurol 71(6):743~752
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