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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 145 - 450 (306page)
- DOI
- 10.14348/molcells.2015.2216
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초록· 키워드
오류제보하기
Continuous intra- and extracellular stresses induce disorder of Ca2+ homeostasis and accumulation of unfolded protein in the endoplasmic reticulum (ER), which results in ER stress. Severe long-term ER stress triggers apoptosis signaling pathways, resulting in cell death. Neural epidermal growth factor-like like protein 2 (NELL2) has been reported to be important in protection of cells from cell death-inducing environments. In this study, we investigated the cytoprotective effect of NELL2 in the context of ER stress induced by thapsigargin, a strong ER stress inducer, in Cos7 cells. Overexpression of NELL2 prevented ER stress-mediated apoptosis by decreasing expression of ER stress-induced C/EBP homologous protein (CHOP) and increasing ER chaperones. In this context, expression of anti-apoptotic Bcl-xL was increased by NELL2, whereas NELL2 decreased expression of pro-apoptotic proteins, such as cleaved caspases 3 and 7. This antiapoptotic effect of NELL2 is likely mediated by extracellular signal-regulated kinase (ERK) signaling, because its inhibitor, U0126, inhibited effects of NELL2 on the expression of anti- and pro-apoptotic proteins and on the protection from ER stress-induced cell death.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Aihara, K. / 2003 / A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases / Mol. Brain Res 116:86~93
Allan, L. A. / 2003 / Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK / Nat. Cell. Biol 5:647~654
Behl, C. / 1995 / 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro / Biochem. Biophys. Res. Commun 216:473~482
Boucher, M. J. / 2000 / MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells / J. Cell. Biochem 79:355~369
Boulares, A. H. / 1999 / Role of poly(ADP-ribose)polymerase(PARP)cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells / J. Biol. Chem 274:22932~22940
Allan, L. A. / 2003 / Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK / Nat. Cell. Biol 5:647~654
Behl, C. / 1995 / 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro / Biochem. Biophys. Res. Commun 216:473~482
Boucher, M. J. / 2000 / MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells / J. Cell. Biochem 79:355~369
Boulares, A. H. / 1999 / Role of poly(ADP-ribose)polymerase(PARP)cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells / J. Biol. Chem 274:22932~22940
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