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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 186 - 194 (9page)
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초록· 키워드
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A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in mammal. We investigated here a possible involvement of central NELL2 in regulating feeding behavior and metabolism. In situ hybridization and an immunohistochemical approach were used to determine expression of NELL2 as well as its colocalization with proopio-melanocortin (POMC) and neuropeptide Y (NPY) in the rat hypothalamus. To investigate the effect of NELL2 on feeding behavior, 2 nmole of antisense NELL2 oligodeoxynucleotide was administered into the lateral ventricle of adult male rat brains for 6 consecutive days, and changes in daily body weight, food, and water intake were monitored. Metabolic state-dependent NELL2 expression in the hypothalamus was tested in vivo using a fasting model. NELL2 was noticeably expressed in the hypothalamic nuclei controlling feeding behavior. Furthermore, all arcuatic POMC and NPY positive neurons produced NELL2. The NELL2 gene expression in the hypothalamus was up-regulated by fasting. However, NELL2 did not affect POMC and NPY gene expression in the hypothalamus. A blockade of NELL2 production in the hypothalamus led to a reduction in daily food intake, followed by a loss in body weight without a change in daily water intake in normal diet condition. NELL2 did not affect short-term hunger dependent appetite behavior. Our data suggests that hypothalamic NELL2 is associated with appetite behavior, and thus central NELL2 could be a new therapeutic target for obesity.
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참고문헌 (39)
참고문헌 신청
Aihara, K. / 2003 / A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases / Brain Res. Mol. Brain Res 116:86~93
Baskin, D. G. / 1999 / Leptin binding in the arcuate nucleus is increased during fasting / Brain Res 828:154~158
Butera, P.C. / 1989 / Central implants of diluted estradiol: independent effects on ingestive and reproductive behaviors of ovariectomized rats / Brain Res 491:266~273
Choi, E. J. / 2010 / Estrogendependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death / J. Biol. Chem 285:25074~25084
Choi, E. J. / 2001 / Low-density cDNA array-coupled to PCR differential display identifies new estrogen-responsive genes during the postnatal differentiation of the rat hypothalamus / Brain Res. Mol. Brain Res 97:115~128
Baskin, D. G. / 1999 / Leptin binding in the arcuate nucleus is increased during fasting / Brain Res 828:154~158
Butera, P.C. / 1989 / Central implants of diluted estradiol: independent effects on ingestive and reproductive behaviors of ovariectomized rats / Brain Res 491:266~273
Choi, E. J. / 2010 / Estrogendependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death / J. Biol. Chem 285:25074~25084
Choi, E. J. / 2001 / Low-density cDNA array-coupled to PCR differential display identifies new estrogen-responsive genes during the postnatal differentiation of the rat hypothalamus / Brain Res. Mol. Brain Res 97:115~128
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