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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 280 - 290 (11page)
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Several lines of evidence suggest that endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Protein tyrosine phosphatase 1B (PTP1B) is known to regulate the ER stress signaling pathway, but its role in neuronal systems in terms of ER stress remains largely unknown. Here, we showed that rotenone-induced toxicity in human neuroblastoma cell lines and mouse primary cortical neurons was ameliorated by PTP1B inhibition. Moreover, the increase in the level of ER stress markers (eIF2? phosphorylation and PERK phosphorylation) induced by rotenone treatment was obviously suppressed by concomitant PTP1B inhibition. However, the rotenone-induced production of reactive oxygen species (ROS) was not affected by PTP1B inhibition, suggesting that the neuroprotective effect of the PTP1B inhibitor is not associated with ROS production. Moreover, we found that MG132-induced toxicity involving proteasome inhibition was also ameliorated by PTP1B inhibition in a human neuroblastoma cell line and mouse primary cortical neurons. Consistently, downregulation of the PTP1B homologue gene in Drosophila mitigated rotenone- and MG132-induced toxicity. Taken together, these findings indicate that PTP1B inhibition may represent a novel therapeutic ap-proach for ER stress-mediated neurodegenerative diseases.
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참고문헌 (51)
참고문헌 신청
Araki, W. / 2000 / Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons / Ann. N. Y. Acad. Sci 920:241~244
Bettaieb, A. / 2012 / Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2 signaling in brown adipocytes / PLoS One 7:e32212
Chen, G. / 2007 / Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons / J. Neurosci. Res 85:1674~1684
Chen, Y. Y. / 2008 / GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells / Biochem. Pharmacol 76:128~138
정지화 / 2015 / Ursodeoxycholic Acid (UDCA) Exerts Anti- Atherogenic Effects by Inhibiting Endoplasmic Reticulum (ER) Stress Induced by Disturbed Flow / Molecules and Cells 38(10):851~858
Bettaieb, A. / 2012 / Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2 signaling in brown adipocytes / PLoS One 7:e32212
Chen, G. / 2007 / Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons / J. Neurosci. Res 85:1674~1684
Chen, Y. Y. / 2008 / GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells / Biochem. Pharmacol 76:128~138
정지화 / 2015 / Ursodeoxycholic Acid (UDCA) Exerts Anti- Atherogenic Effects by Inhibiting Endoplasmic Reticulum (ER) Stress Induced by Disturbed Flow / Molecules and Cells 38(10):851~858
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