지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 210 - 217 (8page)
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초록· 키워드
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The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. However, it remains elusive whether this mechanism is also applicable to senescence amelioration in accelerated aging cells. In this study, we examined the role of ATM inhibition on mitochondrial function in Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) cells. We found that ATM inhibition induced mitochondrial functional recovery accompanied by metabolic reprogramming, which has been known to be a prerequisite for senescence alleviation in normal aging cells. Indeed, the induced mitochondrial metabolic reprogramming was coupled with senescence amelioration in accelerated aging cells. Furthermore, the therapeutic effect via ATM inhibition was observed in HGPS as evidenced by reduced progerin accumulation with concomitant decrease of abnormal nuclear morphology. Taken together, our data indicate that the mitochondrial functional recovery by ATM inhibition might represent a promising strategy to ameliorate the accelerated aging phenotypes and to treat agerelated disease.
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참고문헌 (38)
참고문헌 신청
Azqueta, A. / 2014 / Comet assay to measure DNA repair : approach and applications / Front. Genet 5:288
Benhammou, V. / 2007 / Clinical mitochondrial dysfunction in uninfected children born to HIV-infected mothers following perinatal exposure to nucleoside analogues / Environ. Mol. Mutagen 48:173~178
Brand, Martin D. / 2011 / Assessing mitochondrial dysfunction in cells / Biochem. J 435:297~312
Brunk, U. T. / 2002 / Lipofuscin : mechanisms of agerelated accumulation and influence on cell function / Free Radic. Biol. Med 33:611~619
Cocheme, H. M. / 2008 / Complex I is the major site of mitochondrial superoxide production by paraquat / J. Biol. Chem 283:1786~1798
Benhammou, V. / 2007 / Clinical mitochondrial dysfunction in uninfected children born to HIV-infected mothers following perinatal exposure to nucleoside analogues / Environ. Mol. Mutagen 48:173~178
Brand, Martin D. / 2011 / Assessing mitochondrial dysfunction in cells / Biochem. J 435:297~312
Brunk, U. T. / 2002 / Lipofuscin : mechanisms of agerelated accumulation and influence on cell function / Free Radic. Biol. Med 33:611~619
Cocheme, H. M. / 2008 / Complex I is the major site of mitochondrial superoxide production by paraquat / J. Biol. Chem 283:1786~1798
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