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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 771 - 780 (10page)
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초록· 키워드
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Angiogenesis must be precisely controlled because uncontrolled angiogenesis is involved in aggravation of disease symptoms. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) signaling is a key pathway leading to angiogenic responses in vascular endothelial cells (ECs). Therefore, targeting VEGF/VEGFR-2 signaling may be effective at modulating angiogenesis to alleviate various disease symptoms. Oleanolic acid was verified as a VEGFR-2 binding chemical from anticancer herbs with similar binding affinity as a reference drug in the Protein Data Bank (PDB) entry 3CJG of model A coordination. Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HUVECs without cytotoxicity. We also verified that oleanolic acid inhibits in vivo angiogenesis during the development and the course of the retinopathy of prematurity (ROP) model in the mouse retina. Taken together, our results suggest a potential therapeutic benefit of oleanolic acid for inhibiting angiogenesis in proangiogenic diseases, including retinopathy.
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참고문헌 (58)
참고문헌 신청
Adamis, A.P. / 1994 / Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy / Am. J. Ophthalmol. 118:445~450
Aiello, L.P. / 2005 / Angiogenic pathways in diabetic retinopathy / N Eng. J. Med. 353:839~841
Aiello, L.P. / 1994 / Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders / N Eng. J. Med. 331:1480~1487
Arevalo, J.F. / 2009 / Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months / Ophthalmology 116:1488~1497;1497e1481
Arevalo, J.F. / 2009 / Intravitreal bevacizumab (Avastin) for proliferative diabetic retinopathy: 6-months follow-up / Eye (Lond) 23:117~123
Aiello, L.P. / 2005 / Angiogenic pathways in diabetic retinopathy / N Eng. J. Med. 353:839~841
Aiello, L.P. / 1994 / Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders / N Eng. J. Med. 331:1480~1487
Arevalo, J.F. / 2009 / Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months / Ophthalmology 116:1488~1497;1497e1481
Arevalo, J.F. / 2009 / Intravitreal bevacizumab (Avastin) for proliferative diabetic retinopathy: 6-months follow-up / Eye (Lond) 23:117~123
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