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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제5호
- 발행연도
- 2015.9
- 수록면
- 421 - 426 (6page)
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초록· 키워드
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The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet- derived growth factor (PDGF) is believed to play a central role in the etiology of these pathophysiological situations. Here, we investigated the anti-proliferative effects and possible mechanism(s) of murrayafoline A, a carbazole alkaloid isolated from Glycosmis stenocarpa Guillamin (Rutaceae), on PDGF-BB-stimulated VSMCs. Murrayafoline A inhibited the PDGF-BB-stimulated proliferation of VSMCs in a concentration-dependent manner, as measured using a non-radioactive colorimetric WST-1 assay and direct cell counting. Furthermore, murrayafoline A suppressed the PDGF-BB-stimulated progression through G0/G1 to S phase of the cell cycle, as measured by [3H]-thymidine incorporation assay and cell cycle progression analysis. This anti-proliferative action of murrayafoline A, arresting cell cycle progression at G0/G1 phase in PDGF-BB-stimulated VSMCs, was mediated via down-regulation of the expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2, CDK4, and proliferating cell nuclear antigen (PCNA), and the phosphorylation of retinoblastoma protein (pRb). These results indicate that murrayafoline A may be useful in preventing the progression of vascular complications such as restenosis after percutaneous transluminal coronary angioplasty and atherosclerosis.
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참고문헌 (30)
참고문헌 신청
Ross R / 1993 / The pathogenesis of atherosclerosis: a perspective for the 1990s / Nature 362:801~809
Raines EW / 1993 / Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis / Br Heart J 69(1 Suppl):S30~S37
Millette E / 2006 / Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells / Trends Cardiovasc Med 16:25~28
Bornfeldt KE / 1995 / Distinct signal transduction pathways associated with migration versus proliferation / Ann N Y Acad Sci 766:416~430
Sachinidis A / 1990 / The plateletderived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms / FEBS Lett 275:95~98
Raines EW / 1993 / Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis / Br Heart J 69(1 Suppl):S30~S37
Millette E / 2006 / Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells / Trends Cardiovasc Med 16:25~28
Bornfeldt KE / 1995 / Distinct signal transduction pathways associated with migration versus proliferation / Ann N Y Acad Sci 766:416~430
Sachinidis A / 1990 / The plateletderived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms / FEBS Lett 275:95~98
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