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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제2호
- 발행연도
- 2021.1
- 수록면
- 217 - 225 (9page)
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This study aimed to investigate the neuroprotective effects of 1-methoxylespeflorin G11 (MLG), a pterocarpan, against glutamate-induced neurotoxicity in neuronal HT22 hippocampal cells. The protective effects of MLG were evaluated using MTT assay and microscopic analysis. The extent of apoptosis was studied using flow cytometric analysis performed on the damaged cells probed with annexin V/propidium iodide. Moreover, mitochondrial reactive oxygen species (ROS) were assessed using flow cytometry through MitoSOXTM Red staining. To determine mitochondrial membrane potential, staining with tetramethylrhodamine and JC-1 was performed followed by flow cytometry. The results demonstrated that MLG attenuates glutamate-induced apoptosis in HT22 cells by inhibiting intracellular ROS generation and mitochondrial dysfunction. Additionally, MLG prevented glutamate-induced apoptotic pathway in HT22 cells through upregulation of Bcl-2 and downregulation of cleaved PARP-1, AIF, and phosphorylated MAPK cascades. In addition, MLG treatment induced HO-1 expression in HT22 cells. These results suggested that MLG exhibits neuroprotective effects against glutamate-induced neurotoxicity in neuronal HT22 cells by inhibiting oxidative stress and apoptosis.
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참고문헌 (21)
참고문헌 신청
Crous-Bou M / 2017 / Alzheimer’s disease prevention : from risk factors to early intervention / Alzheimer's Res. Ther 9:71
Grodzicki W / 2020 / The role of selected bioactive compounds in the prevention of Alzheimer’s Disease / Antioxidants 9:229
Woo Y / 2020 / Neuroprotective effects of Euonymus alatus extract on scopolamine-induced memory deficits in mice / Antioxidants 9:449
Park CH / 2019 / Neuroprotective effects of tetrahydrocurcumin against glutamateinduced oxidative stress in hippocampal HT22 cells / Molecules 25:144
김동휘 / 2019 / Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells / Journal of Ginseng Research 43(2):326~334
Grodzicki W / 2020 / The role of selected bioactive compounds in the prevention of Alzheimer’s Disease / Antioxidants 9:229
Woo Y / 2020 / Neuroprotective effects of Euonymus alatus extract on scopolamine-induced memory deficits in mice / Antioxidants 9:449
Park CH / 2019 / Neuroprotective effects of tetrahydrocurcumin against glutamateinduced oxidative stress in hippocampal HT22 cells / Molecules 25:144
김동휘 / 2019 / Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells / Journal of Ginseng Research 43(2):326~334
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