Assessment of In vitro Antioxidant, Antidiabetic and Cytotoxic Activities of Sphaeranthus africanus Extracts

Tran Thi Huyen; Julien Dujardin; Nguyen Thi Thu Huong; Chung Thi My Duyen; Nguyen Hoang Minh; Ha Quang Thanh; Dao Tran Mong; Ly Hai Trieu; Nguyen Mai Truc Tien; Mai Thanh Chung; Nguyen Nhat Minh; Nguyen Thi Ngoc Dan; Huynh Loi

doi:10.20307/nps.2023.29.2.98

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자료유형: 학술저널

저자정보: Tran Thi Huyen (Vietnam National University) Julien Dujardin (Research Center of Ginseng and Medicinal Materials) Nguyen Thi Thu Huong (Research Center of Ginseng and Medicinal Materials) Chung Thi My Duyen (Research Center of Ginseng and Medicinal Materials) Nguyen Hoang Minh (Research Center of Ginseng and Medicinal Materials) Ha Quang Thanh (Research Center of Ginseng and Medicinal Materials) Dao Tran Mong (Research Center of Ginseng and Medicinal Materials) Ly Hai Trieu (Research Center of Ginseng and Medicinal Materials) Nguyen Mai Truc Tien (Research Center of Ginseng and Medicinal Materials) Mai Thanh Chung (Research Center of Ginseng and Medicinal Materials) Nguyen Nhat Minh (Research Center of Ginseng and Medicinal Materials) Nguyen Thi Ngoc Dan (Research Center of Ginseng and Medicinal Materials) Huynh Loi (Binh Duong University)

저널정보: 한국생약학회 Natural Product Sciences Natural Product Sciences Vol.29 No.2

발행연도: 2023.6

수록면: 98 - 103 (6page)

DOI: 10.20307/nps.2023.29.2.98

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Sphaeranthus africanus is commonly used as a traditional remedy for sore throats and pain treatment in Vietnam. The aerial parts have been studied for its anti-inflammatory and anti-proliferative properties. However, the antioxidant and antidiabetic potential of the plant has not been explored. In this work, hydrophilic extracts of the plant’s aerial parts were prepared in order to investigate its antioxidant and anti-diabetic properties. Also, the cytotoxicity of the root was evaluated and compared to that of the aerial parts. All of the extracts inhibited lipid peroxidation with IC<SUB>50</SUB> values ranging from 2.05 to 3.56 ㎍/mL, indicating substantial antioxidant activity. At an IC<SUB>50</SUB> value of 4.80 ㎍/mL, the 50% ethanol extract exhibited the most potent inhibition of α- glucosidase. The cytotoxic activity of root extracts is 2 to 5-fold less than that of the aerial parts. Nevertheless, dichloromethane and ethyl acetate extracts of the root demonstrated a selective effect on leukemia cells, with no harm towards the normal HEK-293 cell line. This work provides a scientific support for the antioxidant and antidiabetic activity of the plant. Hence, it may find a promising material for the development of novel antioxidant and antidiabetic agents. More research can be conducted on the phytochemistry and anticancer activities of the plant’s root.

#Sphaeranthus africanus #Antioxidant #Antidiabetic #Anti-proliferative activities

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이 논문의 저자 정보

Tran Thi Huyen

소속기관 Vietnam National University

주요연구분야 의약학 > 약학

논문수 1 이용수 17

Julien Dujardin