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논문 기본 정보

자료유형
학술저널
저자정보
Osmolovskiy Alexander A. (Department of Microbiology Faculty of Biology Lomonosov Moscow State University Moscow 119234 Russi) Zvonareva Elena S. (Higher School of Economics - National Research University Moscow 109028 Russian Federation) Baranova Nina A. (Department of Microbiology Faculty of Biology Lomonosov Moscow State University Moscow 119234 Russi) Kreyer Valeriana G. (Department of Microbiology Faculty of Biology Lomonosov Moscow State University Moscow 119234 Russi)
저널정보
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제51권 제2호
발행연도
2023.6
수록면
167 - 173 (7page)
DOI
10.48022/mbl.2205.05002

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초록· 키워드

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Proteolytic enzymes secreted by Aspergillus, as pathogenicity factors, affect blood coagulation and fibrinolysis, and therefore the target proteins of their action in the bloodstream are of significant interest. In the present study, the action of the isolated protease of A. terreus 2 on different human plasma proteins was shown. The protease of A. terreus 2 exhibited the highest proteolytic activity against hemoglobin, which was 2.5 times higher than the albuminolytic activity shown in both of the protein substrates used. In addition, the protease has significant ability to hydrolyze both fibrin and fibrinogen. However, the inability of the A. terreus 2 protease to coagulate rabbit blood plasma and coagulate human and bovine fibrinogen indicates the severity of the enzyme's action on human blood coagulation factors. It should be considered as a potential indicator of this isolated protease's participation in fungal pathogenesis. The protease shows no hemolytic activity. Furthermore, its activity is insignificantly inhibited by thrombin inhibitors, and is not inhibited by plasmin inhibitors.

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