Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management

Sara Battistella; Francesca D’Arcangelo; Marco Grasso; Alberto Zanetto; Martina Gambato; Giacomo Germani; Marco Senzolo; Francesco Paolo Russo; Patrizia Burra

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자료유형: 학술저널

저자정보: Sara Battistella (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Francesca D’Arcangelo (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Marco Grasso (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Alberto Zanetto (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Martina Gambato (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Giacomo Germani (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Marco Senzolo (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Francesco Paolo Russo (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy) Patrizia Burra (Gastroenterology and Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital University of Padua Padua Italy)

저널정보: 대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권

발행연도: 2023.2

수록면: 286 - 301 (16page)

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Non-alcoholic fatty liver disease (NAFLD) is currently the fastest growing indication to liver transplantation (LT) in Western Countries, both for end stage liver disease and hepatocellular carcinoma. NAFLD/non-alcoholic steatohepatitis (NASH) is often expression of a systemic metabolic syndrome; therefore, NAFLD/NASH patients require a multidisciplinary approach for a proper pre-surgical evaluation, which is important to achieve a post-transplant outcome comparable to that of other indications to LT. NAFLD/NASH patients are also at higher risk of post-transplant cardiovascular events, diabetes, dyslipidemia, obesity, renal impairment and recurrent NASH. Lifestyle modifications, included diet and physical activity, are key to improve survival and quality of life after transplantation. A tailored immunosuppressive regimen may be proposed in selected patients. Development of new drugs for the treatment of recurrent NASH is awaited.

#NAFLD #NASH #Liver transplantation #Cardiovascular risk #Metabolic syndrome

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