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논문 기본 정보

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저자정보
Cha Hyunkyung (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.Department of Otorhinolaryngology-Hea) Lim Hee-Suk (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.) Park Jin-A (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.Department of Otorhinolaryngology-Hea) Jo Ara (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.) Ryu Hyun Tae (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.) Kim Do Won (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.) Kim Jeong Kyou (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.) Hong Seung-No (Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine Seoul National University Boramae Medical Center Seoul Korea.Sensory Organ Research Institute Seou) Shin Hyun-Woo (Sensory Organ Research Institute Seoul National University Medical Research Center Seoul Korea.) 김대우 (Department of Otorhinolaryngology-Head and Neck Surgery Boramae Medical Center; Seoul Korea)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.1
발행연도
2023.1
수록면
94 - 108 (15page)
DOI
10.4168/aair.2023.15.1.94

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Purpose: This study investigated the clinical implications of neutrophil extracellular trap (NET) formation (NETosis) and eosinophil extracellular trap (EET) formation (EETosis) regarding refractoriness in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). Methods: Nasal polyp specimens were obtained from 117 patients with CRSwNP who received endoscopic sinus surgery. Disease control status at postoperative 1 year was assessed. Refractory cases were defined as partly controlled or uncontrolled cases according to the EPOS 2020 guidelines. NETosis and EETosis were evaluated through immunofluorescence staining (citrullinated histone H3-human neutrophil elastase and citrullinated histone-galectin-10, respectively) followed by manual counting. The z-score of NET and EET counts was used to define the following four groups: low extracellular trap formation (ETosis), NETosis-predominant, EETosis-predominant, and high-ETosis. Results: The refractory and non-refractory groups showed significant differences in the tissue eosinophil count (P = 0.005) and EET count (P = 0.029). The tissue neutrophil count and the NET/neutrophil ratio were significantly different between the refractory and non-refractory groups of patients with neutrophilic CRS (P = 0.045, 0.031, respectively). Refractoriness significantly differed among the low-ETosis (30.77%), NETosis-predominant (47.83%), EETosis-predominant (56.67%), and high-ETosis (83.33%) groups (P = 0.005). Conclusions: The results of this study suggest that tissue Eosinophilia and EETosis may play a prognostic role, primarily in CRSwNP and thattissue neutrophilia and NETosis can play as prognostic biomarkers in neutrophilic CRSwNP.
#Sinusitis #nasal polyps #extracellular DNA traps #eosinophils #neutrophils #allergy #immunology #biomarker

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