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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 5 (5page)
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Systemic corticosteroids currently represent the most effective treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but their long-term use is constrained due to their detrimental side effects. Until recently, development of novel drugs for CRSwNP has been difficult partly due to the absence of a standard animal model of CRSwNP. Exotoxins of Staphylococcus aureus such as staphylococcal enterotoxin B (SEB), are well-known superantigens which can induce a strong immune response; there have been many studies on the association of staphylococcal enterotoxins and development of CRSwNP over the past two decades. Based on previous studies, we invented a mouse model of CRSwNP using SEB. Herein, we explain the protocol development for the mouse model, as well as identify histological and immunological similarities between this mouse model and humans. Furthermore, we describe a study that analyzed the risk factors for CRSwNP such as smoking, and also elaborate on a series of studies that searched for new potential drugs for CRSwNP, including resveratrol, anti-periostin antibody, topical hypoxia-inducible factors, and topical cyclosporine. Based on preceding studies, we have concluded that this mouse model might be a useful tool to investigate the pathophysiology and development of novel drugs for CRSwNP
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참고문헌 (34)
참고문헌 신청
Banerji A / 2007 / Chronic rhinosinusitis patients with polyps or polypoid mucosa have a greater burden of illness / American Journal of Rhinology 21(1):19~26
Kalish L / 2012 / Topical steroids for nasal polyps / Cochrane Database Syst Rev 12:CD006549
Benítez P / 2006 / A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps / Laryngoscope 116(5):770~775
Bachert C / 2005 / Pharmacological management of nasal polyposis / Drugs 65(11):1537~1552
Gevaert P / 2011 / Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis / J Allergy Clin Immunol 128(5):989~995
Kalish L / 2012 / Topical steroids for nasal polyps / Cochrane Database Syst Rev 12:CD006549
Benítez P / 2006 / A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps / Laryngoscope 116(5):770~775
Bachert C / 2005 / Pharmacological management of nasal polyposis / Drugs 65(11):1537~1552
Gevaert P / 2011 / Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis / J Allergy Clin Immunol 128(5):989~995
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Chronic Rhinosinusitis With Nasal Polyps Does Not Affect the Association Between the Nasal Provocation Test and Serum Allergen-Specific Immunoglobulin E Levels
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Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps
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비용종을 동반한 만성 비부비동염 치료에서 생물학적 제제의 최신 지견
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비용종을 동반한 만성 비부비동염의 바이오마커: 내재형에 기초한 맞춤의료
대한이비인후-두경부외과학회지
2019 .01
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A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
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Distinct Inflammatory Profiles in Atopic and Nonatopic Patients With Chronic Rhinosinustis Accompanied by Nasal Polyps in Western China
Allergy, Asthma & Immunology Research
2015 .01
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Vγ1+ γδT Cells Are Correlated With Increasing Expression of Eosinophil Cationic Protein and Metalloproteinase-7 in Chronic Rhinosinusitis With Nasal Polyps Inducing the Formation of Edema
Allergy, Asthma & Immunology Research
2017 .01
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Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp
Allergy, Asthma & Immunology Research
2020 .01
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내재형에 따른 비용종을 동반한 만성 비부비동염의 새로운 병태생리
대한이비인후-두경부외과학회지
2017 .01
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Local Allergic Inflammation in Chronic Rhinosinusitis With Nasal Polyps Could Influence on Disease Severity and Olfaction
Journal of Rhinology
2021 .11
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Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis
Clinical and Experimental Otorhinolaryngology
2018 .01
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Development, Validation and Comparison of Artificial Neural Network and Logistic Regression Models Predicting Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2023 .01
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Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
Clinical and Experimental Otorhinolaryngology
2021 .11
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Effects of Neutrophil and Eosinophil Extracellular Trap Formation on Refractoriness in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2023 .01
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비용의 조직학적 분류에 따른 만성 비부비동염의임상적 특징과 IL-33과 IL-25의 발현
Journal of Rhinology
2015 .01
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Differential Hrd1 Expression and B-Cell Accumulation in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2018 .01
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Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population
Allergy, Asthma & Immunology Research
2020 .01
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The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis
Clinical and Experimental Otorhinolaryngology
2016 .12
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