A case of nearly complete response in hepatocellular carcinoma with disseminated lung metastasis by combination therapy of nivolumab and ipilimumab after treatment failure of atezolizumab plus bevacizumab

김형준; 황상연; 임정우; 전기정; 전완

doi:10.17998/jlc.2023.02.23

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자료유형: 학술저널

저자정보: 김형준 (Departments of 1Internal Medicine Dongnam Institute of Radiological & Medical Sciences Busan Korea) 황상연 (동남권원자력의학원) 임정우 (Departments of 1Internal Medicine Dongnam Institute of Radiological & Medical Sciences Busan Korea) 전기정 (Departments of Internal Medicine Dongnam Institute of Radiological) 전완 (동남권원자력의학원)

저널정보: 대한간암학회 Journal of Liver Cancer Journal of Liver Cancer 제23권 제1호

발행연도: 2023.3

수록면: 213 - 218 (6page)

DOI: 10.17998/jlc.2023.02.23

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Recently, the efficacy of immuno-oncologic agents for advanced hepatocellular carcinoma (HCC) has been proven in several trials. In particular, atezolizumab with bevacizumab (AteBeva), as a first-line therapy for advanced HCC, has shown tremendous advances in the IMBrave150 study. However, second or third-line therapy after treatment failure with AteBeva has not been firmly established. Moreover, clinicians have continued their attempts at multidisciplinary treatment that includes other systemic therapy and radiotherapy (RT). Here, we report a case that showed a near complete response (CR) of lung metastasis to nivolumab with ipilimumab therapy after achieving a near CR of intrahepatic tumor using sorafenib and RT in a patient with advanced HCC who had experienced treatment failure of AteBeva.

#Atezolizumab #Bevacizumab #Radiotherapy #Nivolumab #Ipilimumab

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김형준

소속기관 Departments of 1Internal Medicine Dongnam Institute of Radiological & Medical Sciences Busan Korea