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논문 기본 정보

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학술저널
저자정보
Veronica Natalia (Department of Pharmacy, National University of Singapore, Singapore) Loh Yi Ying (Department of Pharmacy, National University of Singapore, Singapore) Loh Lydia Xiu Ying (Department of Pharmacy, National University of Singapore, Singapore) Heng Paul Wan Sia (Department of Pharmacy, National University of Singapore, Singapore) Liew Celine Valeria (School of Pharmacy, Monash University Malaysia, Malaysia)
저널정보
한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation Vol.54 No.2
발행연도
2024.3
수록면
209 - 227 (19page)
DOI
10.1007/s40005-023-00647-6

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초록· 키워드

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Purpose This study aimed to elucidate the effects magnesium stearate (MgSt) with different physical properties have on powder flow and tablet physical properties. The effects of variation in MgSt chemical properties were also investigated with a focus on the palmitate to stearate (C16/C18) ratio. Methods Lactose blended with 0.25, 0.5 and 1%, w/w of different MgSt grades were evaluated for flow properties. Tablets produced from the mixtures were assessed for tensile strength and ejection force. Results Pearson correlation analysis of high C16/C18 ratio (1.09–1.29) MgSt suggested that increasing C16/C18 ratio could improve flowability and reduce tablet mechanical strength. For low C16/C18 ratio (0.41–0.53) MgSt, increasing C16/C18 ratio only resulted in better flowability. Multivariate analysis showed that the MgSt properties influenced the flowability and tablet physical properties of formulations containing 1%, w/w MgSt. The C16/C18 ratio affected flowability. However, its effect was confounded by MgSt particle size, morphology, crystallinity, and moisture content. Contrastingly, tablet tensile strength was mainly influenced by MgSt particle size, crystallinity, and moisture content, while tablet ejection force was minimally affected by the MgSt properties. Conclusion While the C16/C18 ratio could affect the powder flow properties, the effect was confounded by other MgSt properties. The C16/C18 ratio also had minimal effect on tablet physical properties. The results further showed that although MgSt with smaller particle size, higher crystallinity and moisture content provided better flowability, the resultant tablets had lower tensile strength. These findings highlighted the importance of MgSt properties for formulations of good flowability and tablet physical properties.

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