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논문 기본 정보

자료유형
학술저널
저자정보
Min Young Son (Department of Internal Medicine, Kosin University College of Medicine) Dae Hyeon Cho (Department of Internal Medicine, Kosin University College of Medicine) Sung Eun Kim (Department of Internal Medicine, Kosin University College of Medicine) Seun Ja Park (Department of Internal Medicine, Kosin University College of Medicine) Moo In Park (Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea) Won Moon (Department of Gastroenterology, Kosin University College of Medicine, Busan, Korea) Jae Hyun Kim (Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea) Jung Wook Lee (Department of Internal Medicine, Kosin University College of Medicine) Kyoungwon Jung (Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research 제24권 제3호
발행연도
2024.9
수록면
252 - 258 (7page)

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Objectives: The incidence of adenocarcinomas of the esophagogastric junction (EGJ) and cardia has been gradually increasing in the East. Cancers of the EGJ and gastric cardia have poor prognoses. This study aimed to investigate lymph node metastasis (LNM) rates, their predictive factors, and determine the long-term outcomes of patients with Siewert type II/III early gastric cancer (EGC). Methods: Between January 2014 and June 2022, a total of 573 patients with gastric cancer, including 130 with Siewert type II/III EGC, underwent total gastrectomies at the Kosin University Gospel Hospital. Factors associated with LNM were analyzed using a logistic regression model. Results: Of the 130 patients with Siewert type II/III EGC, 10 (7.7%) demonstrated LNM (LNM-positive group). Macroscopically elevated lesions (I+IIa) (60.0% vs. 16.7%; p=0.009) and lymphovascular invasion (70.0% vs. 5.8%; p<0.001) were more common and the depth of invasion was deeper (p=0.003) in the LNM-positive patients than in the LNMnegative group. Multivariate analysis showed that macroscopically elevated lesions (odds ratio [OR], 19.48; 95% confidence interval [CI], 1.93–197.11; p=0.012) and lymphovascular invasion (OR, 52.63; 95% CI, 5.26–526.51; p=0.001) were associated with LNM. Kaplan–Meier analysis revealed that the 5-year overall and disease-specific survival rates of patients with Siewert type II/III EGC were 90.0% and 98.9%, respectively. During a median follow-up period of 49 months (range, 12–122 months), one patient (0.8%) died owing to gastric cancer recurrence. Conclusions: Patients with Siewert type II/III EGC showed favorable long-term outcomes. Macroscopically elevated lesions and lymphovascular invasion are associated with LNM.

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