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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.3
- 수록면
- 45 - 50 (6page)
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The purpose of this study was to determine the role of substituted groups in phenolic compounds to develop an anticancer agent having strong cytotoxicity against cancer cells but weak against normal cells. The phenolic compounds used in this study were gallic acid and ferulic acid with hydroxyl and carboxyl groups, syringic acid with hydroxyl, carboxyl and methoxy groups, and pyrogallol with hydroxyl groups. Cytotoxicities of these compounds were evaluated by MTT assay for cell viability and XTT assay for cell adhesion activity in normal human skin fibroblast (Detroit 551) and human skin melanoma (SK-MEL-3) cells. Syringic acid, gallic acid and ferulic acid decreased the cell viability and cell adhesion activity in SK-MEL-3 cells but not in Detroit 551 cells while pyrogallol decreased in both cells. The susceptibility of cell viability based on the IC_(50) values of MTT assay in Detroit 551 cells was in the following order: pyrogallol > gallic acid > ferulic acid > syringic acid, while it was in SK-MEL-3 cells: Syringic acid > progallol > ferulic acid > gallic acid. These results suggest that carboxyl and methoxy groups of these compounds play an important role in selectivity of cytotoxicity in normal and cancer cells.
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Ferulic Acid와 관련 페놀화합물의 암세포주에 대한 독성억제효과
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2005 .01
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GC에 의한 인삼 중의 방향족 산성 성분 분석
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1994 .01
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Anticancer Effect of Ferulic Acid on Cultured Human Skin Melanoma Cells
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Toxic Effect on Phenolic Compound by Colorimeteric Assay in Normal NIH 3T3 Fibroblasts
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2004 .09
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Effect of Ferulic Acid on Cell Viability and Cell Adhesion Activity in Normal Human Gingival Fibroblasts
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2004 .09
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Cytotoxic Effect of Syringic Acid on Human Oral Epithelioid Carcinoma Cells
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Neuroprotective effects of caffeic acid, syringic acid and HBU-3 (a synthetic caffeic acid-syringic acid adduct) on the delayed neuronal death induced by transient cerebral ischemia
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Characterization of Physicochemical Properties of Ferulic Acid
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2003 .01
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Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia
Laboratory Animal Research
2012 .12
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GC/MS에 의한 잎담배중 Phenolic Acid의 분석
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천궁으로부터 분리된 ferulic acid의 히알루론산 생성에 미치는 효과
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Plant Phenolics Ferulic Acid and P-Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation through EGFR Down-Regulation
Asian Pacific journal of cancer prevention : APJCP
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Ferulic acid attenuates focal cerebral ischemia-induced decreases in p70S6 kinase and S6 phosphorylation
한국실험동물학회 학술발표대회 논문집
2013 .08
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Ferulic acid prevents the down-regulation of MEK/ERK/p90RSK signaling pathway in focal cerebral ischemic injury
한국실험동물학회 학술발표대회 논문집
2015 .02
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Ferulic acid prevents the injury-induced decrease of γ-enolase expression in brain tissue and HT22 cells
Laboratory Animal Research
2014 .03
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