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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 337 - 341 (5page)
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초록· 키워드
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This study was undertaken to clerify the cytotoxic effect of syringic acid by colorimetric assay on human cancer cells. For the evaluation of cytotoxicity of syringic acid, the cell viability and cell adhesion activity of syringic acid on cancer cells, human oral epithelioid carcinoma cells were determined using by colorimetric assays such as MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and XTT (2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide) assay, respectively after human oral epithelioid carcinoma cells were treated with syringic acid for 48 hours. In this study, the cell viability of syringic acid on human oral epithelioid carcinoma cells showed a significant decrease by MTT assay compared with control, and also, the cell adhesion activity by XTT assay was decreased significantly in these cells after cells were treated with various concentrations of syringic acid for 48 hours. MTT<sub>50</sub> and XTT<sub>50</sub> were 282.3 μM and 418.8 μM syringic acid, respectively, These results suggest that syringic acid shows midcytotoxic effect on human oral epithelioid carcinoma cells by the decreasement of the cell viability and the cell adehision activity assessed by colorimetric assay in these cultures.
목차
영어초록
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (15)
참고문헌 신청
[학술지(정기간행물)] - E,Borenfreund / 1988 / Comparisons of two in vitro cytotoxicity assay. The neutral red(NR) and tetrazolium MTT tests / Toxicol In Vitro. 2 : 1 ~ 8
[학술지(정기간행물)] - JB,De Heredia / 2001 / Kinetic model for phenolic compound oxidation by Fenton's reagent / Chemosphere 45 : 85 ~ 90
[학술지(정기간행물)] - LR,Ferguson / 2001 / Role of plant polyphenols in genomic stability / Mutat Res. 18 : 89 ~ 90
[학술지(정기간행물)] - DM,Goldberg / 1999 / Phenolic constituents, furans, and total antioxidant status of distilled spirits / J Agric Food Chem. 47 : 3978 ~ 3985
[학술지(정기간행물)] - J,Heilmann / 2000 / Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes: structure-activity relationships / Planta Med. 66 : 746 ~ 748
[학술지(정기간행물)] - JB,De Heredia / 2001 / Kinetic model for phenolic compound oxidation by Fenton's reagent / Chemosphere 45 : 85 ~ 90
[학술지(정기간행물)] - LR,Ferguson / 2001 / Role of plant polyphenols in genomic stability / Mutat Res. 18 : 89 ~ 90
[학술지(정기간행물)] - DM,Goldberg / 1999 / Phenolic constituents, furans, and total antioxidant status of distilled spirits / J Agric Food Chem. 47 : 3978 ~ 3985
[학술지(정기간행물)] - J,Heilmann / 2000 / Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes: structure-activity relationships / Planta Med. 66 : 746 ~ 748
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