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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.3 No.1
- 발행연도
- 1998.3
- 수록면
- 62 - 66 (5page)
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The effect of dietary capsaicin(8-methyl-N-vanillyl-6-nonenamide, CAP) on drug-metabolizing enzyme activities was investigated in mice. Male ICR mice were divided into 4 groups and fed diets containing 0, 5, 20, 100ppm CAP for 4 weeks. Hepatic drug-metabolizing enzyme activities and serum alanine aminotransferase and aspartate transaminase activities were measured. There was no difference in hepatic alanine aminotransferase and aspartate transaminase activities among the groups. Hepatic microsomal cytochrome P450 dependent dimethylnitrosamine N-demethylase and ethoxycoumarin-O-deethylase were significantly elevated in CAP fed groups, but p-nitrophenol hydroxylase and the cytosolic activity of glutathione S-transferase activities were decreased in the dietary CAP supplemented groups compared to the control. These results suggest that the dietary CAP at a low dose differentially modulates drug-metabolizing enzyme activities without causing hepatic toxicity.
목차
Abstract
INTRODUCTION
MATERIALS AND METHOD
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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